Cellular mechanisms linking cancers to obesity.
adipokines
cancer
extracellular Matrix remodeling
inflammation
metabolism
mouse models
obesity
Journal
Cell stress
ISSN: 2523-0204
Titre abrégé: Cell Stress
Pays: Austria
ID NLM: 101718867
Informations de publication
Date de publication:
12 Apr 2021
12 Apr 2021
Historique:
entrez:
14
5
2021
pubmed:
15
5
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Obesity is epidemiologically linked to 13 forms of cancer. The local and systemic obese environment is complex and likely affect tumors through multiple avenues. This includes modulation of cancer cell phenotypes and the composition of the tumor microenvironment. A molecular understanding of how obesity links to cancer holds promise for identifying candidate genes for targeted therapy for obese cancer patient. Herein, we review both the cell-autonomous and non-cell-autonomous mechanisms linking obesity and cancer as well as provide an overview of the mouse model systems applied to study this.
Identifiants
pubmed: 33987528
doi: 10.15698/cst2021.05.248
pii: CST0271E112
pmc: PMC8090860
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
55-72Informations de copyright
Copyright: © 2021 Liu et al.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors declare no competing interests.
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