Organic Cation Transporters in Brain Catecholamine Homeostasis.
Catecholamine
Clearance
Dopamine
Epinephrine
Norepinephrine
OCT1
OCT2
OCT3
Organic cation transporter
PMAT
Uptake
Journal
Handbook of experimental pharmacology
ISSN: 0171-2004
Titre abrégé: Handb Exp Pharmacol
Pays: Germany
ID NLM: 7902231
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
15
5
2021
medline:
29
10
2021
entrez:
14
5
2021
Statut:
ppublish
Résumé
Catecholamines, including dopamine, norepinephrine, and epinephrine, are modulatory transmitters released from specialized neurons throughout the brain. Collectively, catecholamines exert powerful regulation of mood, motivation, arousal, and plasticity. Transporter-mediated uptake determines the peak concentration, duration, and physical spread of released catecholamines, thus playing key roles in determining the magnitude and duration of their modulatory effects. Most studies of catecholamine clearance have focused on the presynaptic high-affinity, low-capacity dopamine (DAT), and norepinephrine (NET) transporters, which are members of the uptake
Identifiants
pubmed: 33987762
doi: 10.1007/164_2021_470
doi:
Substances chimiques
Catecholamines
0
Cations
0
Organic Cation Transport Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-197Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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