Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress.
Tau protein
chronic stress
neurogenesis
olfactory bulb
oligodendrogenesis
subventricular zone
Journal
Cell proliferation
ISSN: 1365-2184
Titre abrégé: Cell Prolif
Pays: England
ID NLM: 9105195
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
08
02
2021
received:
07
12
2020
accepted:
03
03
2021
pubmed:
15
5
2021
medline:
13
7
2021
entrez:
14
5
2021
Statut:
ppublish
Résumé
The area of the subventricular zone (SVZ) in the adult brain exhibits the highest number of proliferative cells, which, together with the olfactory bulb (OB), maintains constant brain plasticity through the generation, migration and integration of newly born neurons. Despite Tau and its malfunction is increasingly related to deficits of adult hippocampal neurogenesis and brain plasticity under pathological conditions [e.g. in Alzheimer's disease (AD)], it remains unknown whether Tau plays a role in the neurogenic process of the SVZ and OB system under conditions of chronic stress, a well-known sculptor of brain and risk factor for AD. Different types of newly born cells in SVZ and OB were analysed in animals that lack Tau gene (Tau-KO) and their wild-type littermates (WT) under control or chronic stress conditions. We demonstrate that chronic stress reduced the number of proliferating cells and neuroblasts in the SVZ leading to decreased number of newborn neurons in the OB of adult WT, but not Tau-KO, mice. Interestingly, while stress-evoked changes were not detected in OB granular cell layer, Tau-KO exhibited increased number of mature neurons in this layer indicating altered neuronal migration due to Tau loss. Our findings suggest the critical involvement of Tau in the neurogenesis suppression of SVZ and OB neurogenic niche under stressful conditions highlighting the role of Tau protein as an essential regulator of stress-driven plasticity deficits.
Identifiants
pubmed: 33988263
doi: 10.1111/cpr.13027
pmc: PMC8249793
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13027Subventions
Organisme : European Regional Development Fund
ID : FCOMP-01-0124-FEDER-037298
Organisme : European Regional Development Fund
ID : POCI-01-0145-FEDER-007038
Organisme : Fundação para a Ciência e a Tecnologia
ID : CEECIND/02231/2018
Organisme : Fundação para a Ciência e a Tecnologia
ID : IF/01079/2014
Organisme : Fundação para a Ciência e a Tecnologia
ID : NORTE-01-0145-FEDER-000013
Organisme : Fundação para a Ciência e a Tecnologia
ID : NORTE-01-0145-FEDER-000023
Organisme : Fundação para a Ciência e a Tecnologia
ID : PEst-C/SAU/LA0026/2013
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/50026/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDP/50026/2020
Organisme : Portuguese Platform of Bioimaging
ID : PPBI-POCI-01-0145-FEDER-022122
Informations de copyright
© 2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.
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