Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus.
Aloe-emodin
Anti-cancer
Asphodelus microcarpus
Breast cancer
Metastasis
NF-κB
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
18
03
2021
accepted:
03
05
2021
pubmed:
15
5
2021
medline:
26
11
2021
entrez:
14
5
2021
Statut:
ppublish
Résumé
Anthraquinones are a major class of compounds naturally occurring in Asphodelus microcarpus. The pharmacological actions of anthraquinones in cancer cells are known to induce apoptosis or autophagy, and revert multidrug resistance. In this study, five anthraquinone-type analogs were isolated from the methanol extract of A. microcarpus leaves and identified as, emodin, rhein, physcion, aloe-emodin, and emodic acid. Among them, aloe-emodin and emodic-acid strongly inhibited the proliferation, cells-intrinsic NF-κB activity and metastatic ability of breast cancer. Although aloe-emodin inhibited p38 and ERK phosphorylation, emodic-acid more markedly inhibited JNK, in addition to p38 and ERK phosphorylation. Both aloe-emodin and emodic-acid inhibited the secretion of the pro-tumorigenic cytokines IL-1β and IL-6, and VEGF and MMP expression, and subsequently inhibited the invasive and migratory potential of 4T1 cells. Thus, our study demonstrated the effects of aloe-emodin and emodin-acid in controlling the migratory and invasive ability of 4T1 breast cancer cells, in addition to inhibiting NF-κB activity and the expression of its downstream target molecules.
Identifiants
pubmed: 33988779
doi: 10.1007/s11418-021-01526-w
pii: 10.1007/s11418-021-01526-w
doi:
Substances chimiques
Anthraquinones
0
NF-kappa B
0
Emodin
KA46RNI6HN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
840-853Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 17H06398
Organisme : Otsuka Toshimi Scholarship Foundation
ID : 20-70
Informations de copyright
© 2021. The Japanese Society of Pharmacognosy.
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