The role of salt-inducible kinases on the modulation of renal and intestinal Na
Animals
Arterial Pressure
/ drug effects
Behavior, Animal
/ drug effects
Gastrointestinal Tract
/ drug effects
Gene Knockout Techniques
Heart Rate
/ drug effects
Kidney
/ drug effects
Mice, Inbred C57BL
Mice, Knockout
Protein Serine-Threonine Kinases
/ genetics
Sodium Chloride, Dietary
/ administration & dosage
Sodium-Potassium-Exchanging ATPase
/ metabolism
Time Factors
High-salt intake
Intestinal NKA
Na(+)/K(+)-ATPase (NKA) activity
Renal NKA
SIK1 knockout mouse
SIK2 knockout mouse
Salt-inducible kinase 1 (SIK1)
Salt-inducible kinase 2 (SIK2)
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
05 Aug 2021
05 Aug 2021
Historique:
received:
06
03
2021
revised:
24
04
2021
accepted:
30
04
2021
pubmed:
15
5
2021
medline:
6
11
2021
entrez:
14
5
2021
Statut:
ppublish
Résumé
Type 1 salt-inducible kinases (SIK1) has been shown to act as a mediator during the cellular adaptation to variations in intracellular sodium in a variety of cell types. Type 2 SIK (SIK2) modulates various biological functions and acts as a signal transmitter in various pathways. To evaluate the role of both SIK isoforms in renal and intestinal Na
Identifiants
pubmed: 33989615
pii: S0014-2999(21)00306-X
doi: 10.1016/j.ejphar.2021.174153
pii:
doi:
Substances chimiques
Sodium Chloride, Dietary
0
salt-inducible kinase-2, mouse
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Sik1 protein, mouse
EC 2.7.11.1
Sodium-Potassium-Exchanging ATPase
EC 7.2.2.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
174153Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.