(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells.
(+)-Catechin
(-)-Epicatechin
Apoptosis
Cancer cells
Membrane androgen receptor
ZIP9
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
30
12
2020
revised:
19
04
2021
accepted:
27
04
2021
pubmed:
15
5
2021
medline:
31
8
2021
entrez:
14
5
2021
Statut:
ppublish
Résumé
(-)-Epicatechin, a flavonoid present in high concentrations in foods such as green tea and cocoa, exerts beneficial and protective effects in numerous disease models, including anti-tumorigenesis and apoptosis in human breast and prostate cancer cells. Potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in these cancer cells, were investigated. Both (-)-epicatechin and (+)-catechin were effective competitors of [
Identifiants
pubmed: 33989703
pii: S0960-0760(21)00099-6
doi: 10.1016/j.jsbmb.2021.105906
pii:
doi:
Substances chimiques
AR protein, human
0
Cation Transport Proteins
0
Receptors, Androgen
0
Slc39a9 protein, human
0
Catechin
8R1V1STN48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105906Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.