Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency.

Female Humans Infant, Newborn Intensive Care Units, Neonatal Iron / administration & dosage Iron Deficiencies / blood Male Retrospective Studies
Iron Iron deficiency Quality improvement RET-He Supplementation

Journal

Blood cells, molecules & diseases
ISSN: 1096-0961
Titre abrégé: Blood Cells Mol Dis
Pays: United States
ID NLM: 9509932

Informations de publication

Date de publication:
09 2021
Historique:
received: 22 01 2021
revised: 27 04 2021
accepted: 27 04 2021
pubmed: 15 5 2021
medline: 1 2 2022
entrez: 14 5 2021
Statut: ppublish

Résumé

In order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk infants. Adherence with early iron supplementation guidelines was 73.4% (399/543) with 51% (275/543) having RET-He values obtained at one month. Despite good adherence, 16% (44/275) had RET-He <25 pg (5th percentile for gestational age). No infants receiving red blood cell transfusion (0/20) had RET-He <25 pg vs. 26.1% (40/153) of those treated with darbepoetin (p < 0.001). There was no evidence of increased feeding intolerance (episodes of emesis/day) with early iron supplementation.

Identifiants

DOI: 10.1016/j.bcmd.2021.102575 PMID: 33989937 PMC: PMC9132591
pubmed: 33989937
pii: S1079-9796(21)00041-3
doi: 10.1016/j.bcmd.2021.102575
pmc: PMC9132591
mid: NIHMS1700996
pii:
doi:

Substances chimiques

Iron E1UOL152H7

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

102575

Subventions

Organisme : NIDDK NIH HHS
ID : U54 DK110858
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

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Auteurs

Timothy M Bahr (TM)

Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA. Electronic address: Tim.Bahr@hsc.utah.edu.

Nicholas R Carr (NR)

Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA.

Thomas R Christensen (TR)

University of Utah, Salt Lake City, UT, USA.

Jacob Wilkes (J)

Intermountain Healthcare Research, Salt Lake City, UT, USA.

Elizabeth A O'Brien (EA)

Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Intermountain Healthcare Research, Salt Lake City, UT, USA.

Kendell R German (KR)

Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, WA, USA.

Robin K Ohls (RK)

Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA.

Diane M Ward (DM)

Department of Pathology, University of Utah Health, Salt Lake City, UT, USA; Center for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA.

Robert D Christensen (RD)

Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Intermountain Healthcare Research, Salt Lake City, UT, USA; Center for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Utah Health, Salt Lake City, UT, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early iron supplementation and iron...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Early iron supplementation and iron...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Unités hospitalières › Unités de soins intensifs › Unités de soins intensifs pédiatriques › Unités de soins intensifs néonatals › Early iron supplementation and iron...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Early iron supplementation and iron...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du fer › Carences en fer › Early iron supplementation and iron...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Early iron supplementation and iron...