COVID-19 vaccines in multiple sclerosis treated with cladribine or ocrelizumab.

Antibodies, Monoclonal, Humanized COVID-19 COVID-19 Vaccines Cladribine Humans Multiple Sclerosis SARS-CoV-2
COVID-19 Disease modifying therapy Multiple sclerosis Vaccine

Journal

Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247

Informations de publication

Date de publication:
Jul 2021
Historique:
received: 30 03 2021
revised: 12 04 2021
accepted: 22 04 2021
pubmed: 15 5 2021
medline: 7 7 2021
entrez: 14 5 2021
Statut: ppublish

Résumé

Since the recent approval of vaccines against COVID-19, efficacy concerns emerged for MS patients treated with immunosuppressive drugs. We report our experience in four patients, under cladribine (two) or under ocrelizumab (two) treatment, all with low lymphocyte count, three of them vaccinated after 3 months from the last dose with good immune response, one (under ocrelizumab) after 2 months, without developing an appropriate title of antibodies. This experience suggests that the discriminant for the response to the vaccine is not the lymphocyte count but the timing of the vaccination.

Identifiants

DOI: 10.1016/j.msard.2021.102983 PMID: 33990054 PMC: PMC8093161
pubmed: 33990054
pii: S2211-0348(21)00250-9
doi: 10.1016/j.msard.2021.102983
pmc: PMC8093161
pii:
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
COVID-19 Vaccines 0
Cladribine 47M74X9YT5
ocrelizumab A10SJL62JY

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

102983

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Références

Lancet Infect Dis. 2021 Feb;21(2):e26-e35
pubmed: 33125914
Nat Rev Neurol. 2020 Sep;16(9):493-505
pubmed: 32641860
Eur J Neurol. 2021 Oct;28(10):3384-3395
pubmed: 33340215
J Neurol. 2021 Oct;268(10):3592-3594
pubmed: 33638680
Mult Scler Relat Disord. 2019 Jun;31:173-188
pubmed: 31159998
Neurol Neuroimmunol Neuroinflamm. 2017 Nov 15;5(1):e409
pubmed: 29159204
Neurology. 2020 Oct 6;95(14):e1999-e2008
pubmed: 32727835
Ann Neurol. 2021 Apr;89(4):780-789
pubmed: 33480077
Vaccines (Basel). 2021 Jan 28;9(2):
pubmed: 33525459
Eur J Neurol. 2018 Mar;25(3):527-534
pubmed: 29205701

Auteurs

Fabio Buttari (F)

Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), Italy.

Antonio Bruno (A)

Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), Italy; Synaptic Immunopathology Lab, Department of Systems Medicine, Tor Vergata University, Via Montpellier, 1, Rome 00133, Italy.

Ettore Dolcetti (E)

Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), Italy; Synaptic Immunopathology Lab, Department of Systems Medicine, Tor Vergata University, Via Montpellier, 1, Rome 00133, Italy.

Federica Azzolini (F)

Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), Italy; NEUROFARBA Department, Florence University, Italy.

Paolo Bellantonio (P)

Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), Italy.

Diego Centonze (D)

Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), Italy; Synaptic Immunopathology Lab, Department of Systems Medicine, Tor Vergata University, Via Montpellier, 1, Rome 00133, Italy. Electronic address: centonze@uniroma2.it.

Roberta Fantozzi (R)

Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), Italy.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › COVID-19 vaccines in multiple sclerosis...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › COVID-19 vaccines in multiple sclerosis...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › COVID-19 vaccines in multiple sclerosis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Chloro-2 adénosine › Chloro-2 désoxyadénosine › COVID-19 vaccines in multiple sclerosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › COVID-19 vaccines in multiple sclerosis...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › COVID-19 vaccines in multiple sclerosis...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › COVID-19 vaccines in multiple sclerosis...