Natalizumab discontinuation in a Dutch real-world cohort.


Journal

Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247

Informations de publication

Date de publication:
Jul 2021
Historique:
received: 21 01 2021
revised: 12 04 2021
accepted: 18 04 2021
pubmed: 15 5 2021
medline: 7 7 2021
entrez: 14 5 2021
Statut: ppublish

Résumé

To determine characteristics of multiple sclerosis patients that discontinued natalizumab treatment in a real-world cohort. Data was collected from an ongoing observational cohort study of all natalizumab treated patients at the Amsterdam UMC. Of 253 patients who ever received natalizumab treatment, 147 have discontinued treatment. The most frequent reason for treatment discontinuation was JC-virus (JCV) positivity. JCV positivity seems the most frequent reason for natalizumab discontinuation. The heterogeneity in treatment switches reflects the advances made in treatment options, and underlines the need for adequate patient counselling.

Identifiants

pubmed: 33990055
pii: S2211-0348(21)00241-8
doi: 10.1016/j.msard.2021.102974
pii:
doi:

Substances chimiques

Antibodies, Viral 0
Natalizumab 0

Types de publication

Letter Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

102974

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

E M E Coerver (EME)

Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands. Electronic address: e.coerver@amsterdamumc.nl.

M H J Wessels (MHJ)

Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Z Y G van Lierop (ZYG)

Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Z L E van Kempen (ZLE)

Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.

J Killestein (J)

Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.

E M M Strijbis (EMM)

Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH