Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.

Adult Aged Aged, 80 and over Coffee / adverse effects Cohort Studies CpG Islands DNA Methylation Epigenesis, Genetic Epigenome Female Gene Knockdown Techniques Genome-Wide Association Study Humans Liver / enzymology Male Middle Aged Phosphoglycerate Dehydrogenase / antagonists & inhibitors Risk Factors Tea / adverse effects

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
14 05 2021
Historique:
received: 15 04 2020
accepted: 26 03 2021
entrez: 15 5 2021
pubmed: 16 5 2021
medline: 4 6 2021
Statut: epublish

Résumé

Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10

Identifiants

DOI: 10.1038/s41467-021-22752-6 PMID: 33990564 PMC: PMC8121846
pubmed: 33990564
doi: 10.1038/s41467-021-22752-6
pii: 10.1038/s41467-021-22752-6
pmc: PMC8121846
doi:

Substances chimiques

Coffee 0
Tea 0
Phosphoglycerate Dehydrogenase EC 1.1.1.95

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2830

Subventions

Organisme : NHLBI NIH HHS
ID : N01HC85080
Pays : United States
Organisme : Wellcome Trust
ID : 217065/Z/19/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S020845/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N01HC85082
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC55222
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85086
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268200800007C
Pays : United States
Organisme : Medical Research Council
ID : MR/R023484/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG023629
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080295
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200036C
Pays : United States
Organisme : NHLBI NIH HHS
ID : RC2 HL102419
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS087541
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL103612
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12013_2
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085251
Pays : United States
Organisme : NHLBI NIH HHS
ID : K22 HL135075
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N01HC85079
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85083
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087652
Pays : United States
Organisme : Medical Research Council
ID : MR/L01632X/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N01HC85081
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T019980/1
Pays : United Kingdom

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Auteurs

Irma Karabegović (I)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Department of Genetic Identification, Erasmus University Medical Center, Rotterdam, the Netherlands.
Epidemiology and Microbial Genomics, National Health Laboratory, Dudelange, Luxembourg.

Eliana Portilla-Fernandez (E)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Yang Li (Y)

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Jiantao Ma (J)

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland and the Framingham Heart Study, Framingham, MA, USA.

Silvana C E Maas (SCE)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Department of Genetic Identification, Erasmus University Medical Center, Rotterdam, the Netherlands.

Daokun Sun (D)

Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Emily A Hu (EA)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Brigitte Kühnel (B)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Yan Zhang (Y)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0001-9913-6490

Srikant Ambatipudi (S)

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
AMCHSS, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, Cedex 08, France.
ORCID: 0000-0003-3102-3603

Giovanni Fiorito (G)

Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.

Jian Huang (J)

MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
UK Dementia Research Institute at Imperial College London, London, UK.
Imperial College NIHR Biomedical Research Centre, London, UK.

Juan E Castillo-Fernandez (JE)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Epigenetics Programme, Babraham Institute, Cambridge, UK.
ORCID: 0000-0002-0034-8029

Kerri L Wiggins (KL)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU, Seattle, WA, USA.
ORCID: 0000-0003-2749-1279

Niek de Klein (N)

Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
ORCID: 0000-0003-4640-9904

Sara Grioni (S)

Epidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.

Brenton R Swenson (BR)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU, Seattle, WA, USA.

Silvia Polidoro (S)

MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
Italian Institute for Genomic Medicine (IIGM, former HuGeF), c/o IRCCS Candiolo, Candiolo, Italy.
ORCID: 0000-0003-2968-0575

Jorien L Treur (JL)

Department of Psychiatry, Amsterdam UMC, Amsterdam, the Netherlands.

Cyrille Cuenin (C)

Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, Cedex 08, France.

Pei-Chien Tsai (PC)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.
Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan.

Ricardo Costeira (R)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.

Veronique Chajes (V)

Nutritional Epidemiology Group, International Agency for Research on Cancer, Lyon, France.

Kim Braun (K)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0001-8738-4139

Niek Verweij (N)

Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Genomics plc, Park End St, Oxford, UK.
ORCID: 0000-0002-4303-7685

Anja Kretschmer (A)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Lude Franke (L)

Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Joyce B J van Meurs (JBJ)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

André G Uitterlinden (AG)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0002-7276-3387

Robert J de Knegt (RJ)

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.

M Arfan Ikram (MA)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-0372-8585

Abbas Dehghan (A)

MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
UK Dementia Research Institute at Imperial College London, London, UK.

Annette Peters (A)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0001-6645-0985

Ben Schöttker (B)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Sina A Gharib (SA)

Computational Medicine Core at Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.

Nona Sotoodehnia (N)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU, Seattle, WA, USA.

Jordana T Bell (JT)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
ORCID: 0000-0002-3858-5986

Paul Elliott (P)

MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
UK Dementia Research Institute at Imperial College London, London, UK.
Imperial College NIHR Biomedical Research Centre, London, UK.
Health Data Research UK-London, London, UK.
ORCID: 0000-0002-7511-5684

Paolo Vineis (P)

MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.

Caroline Relton (C)

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Zdenko Herceg (Z)

Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, Cedex 08, France.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Network Aging Research, University of Heidelberg, Heidelberg, Germany.

Melanie Waldenberger (M)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0003-0583-5093

Casey M Rebholz (CM)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
ORCID: 0000-0002-5442-8745

Trudy Voortman (T)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-2830-6813

Qiuwei Pan (Q)

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0001-9982-6184

Myriam Fornage (M)

Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
ORCID: 0000-0003-0677-8158

Daniel Levy (D)

Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland and the Framingham Heart Study, Framingham, MA, USA.

Manfred Kayser (M)

Department of Genetic Identification, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-4958-847X

Mohsen Ghanbari (M)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. m.ghanbari@erasmusmc.nl.
Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. m.ghanbari@erasmusmc.nl.
ORCID: 0000-0002-9476-7143

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