Technological tools and strategies for culturing human gut microbiota in engineered in vitro models.
anaerobiosis
bioreactors
gut-brain axis
microfluidic systems
organ-on-a-chip
Journal
Biotechnology and bioengineering
ISSN: 1097-0290
Titre abrégé: Biotechnol Bioeng
Pays: United States
ID NLM: 7502021
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
29
03
2021
received:
22
11
2020
accepted:
04
05
2021
pubmed:
16
5
2021
medline:
18
1
2022
entrez:
15
5
2021
Statut:
ppublish
Résumé
The gut microbiota directly impacts the pathophysiology of different human body districts. Consequently, microbiota investigation is an hot topic of research and its in vitro culture has gained extreme interest in different fields. However, the high sensitivity of microbiota to external stimuli, such as sampling procedure, and the physicochemical complexity of the gut environment make its in vitro culture a challenging task. New engineered microfluidic gut-on-a-chip devices have the potential to model some important features of the intestinal structure, but they are usually unable to sustain culture of microbiota over an extended period of time. The integration of gut-on-a-chip devices with bioreactors for continuous bacterial culture would lead to fast advances in the study of microbiota-host crosstalk. In this review, we summarize the main technologies for the continuous culture of microbiota as upstream systems to be coupled with microfluidic devices to study bacteria-host cells communication. The engineering of integrated microfluidic platforms, capable of sustaining both anaerobic and aerobic cultures, would be the starting point to unveil complex biological phenomena proper of the microbiota-host crosstalks, paving to way to multiple research and technological applications.
Identifiants
pubmed: 33990954
doi: 10.1002/bit.27816
pmc: PMC8361989
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2886-2905Informations de copyright
© 2021 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals LLC.
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