The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study.
bladder cancer
cancer prevalence
haematuria
hematuria
prostate cancer
renal cancer
upper tract urothelial cancer
urinary tract cancer
Journal
BJU international
ISSN: 1464-410X
Titre abrégé: BJU Int
Pays: England
ID NLM: 100886721
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
27
04
2021
received:
26
02
2021
accepted:
06
05
2021
pubmed:
16
5
2021
medline:
30
11
2021
entrez:
15
5
2021
Statut:
ppublish
Résumé
To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries. Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3-34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1-30.2), UTUC (n = 128) 1.14% (95% CI 0.77-1.52), renal cancer (n = 107) 1.05% (95% CI 0.80-1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32-2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03-1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90-4.15; P < 0.001), male sex 1.30 (95% CI 1.14-1.50; P < 0.001), and smoking 2.70 (95% CI 2.30-3.18; P < 0.001). A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer.
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
440-450Subventions
Organisme : Chief Scientist Office
ID : HSRU1
Pays : United Kingdom
Investigateurs
Aasem Chaudry
(A)
Abhishek Sharma
(A)
Adam Bennett
(A)
Adnan Ahmad
(A)
Ahmed Abroaf
(A)
Ahmed M Suliman
(AM)
Aimee Lloyd
(A)
Alastair McKay
(A)
Albert Wong
(A)
Alberto Silva
(A)
Alexandre Schneider
(A)
Alison MacKay
(A)
Allen Knight
(A)
Alkiviadis Grigorakis
(A)
Amar Bdesha
(A)
Amy Nagle
(A)
Ana Cebola
(A)
Ananda Kumar Dhanasekaran
(AK)
Andraž Kondža
(A)
André Barcelos
(A)
Andrea B Galosi
(AB)
Andrea Ebur
(A)
Andrea Minervini
(A)
Andrew Russell
(A)
Andrew Webb
(A)
Ángel García de Jalón
(Á)
Ankit Desai
(A)
Anna K Czech
(AK)
Anna Mainwaring
(A)
Anthony Adimonye
(A)
Arighno Das
(A)
Arnaldo Figueiredo
(A)
Arnauld Villers
(A)
Artur Leminski
(A)
Arvinda Chippagiri
(A)
Asıf Yıldırım
(A)
Athanasios M Voulgaris
(AM)
Audrey Uzan
(A)
Aye Moh Moh Oo
(AMM)
Ayman Younis
(A)
Bachar Zelhof
(B)
Bashir Mukhtar
(B)
Ben Ayres
(B)
Ben Challacombe
(B)
Benedict Sherwood
(B)
Benjamin Ristau
(B)
Billy Lai
(B)
Brechtje Nellensteijn
(B)
Brielle Schreiter
(B)
Carlo Trombetta
(C)
Catherine Dowling
(C)
Catherine Hobbs
(C)
Cayo Augusto Estigarribia Benitez
(CAE)
Cédric Lebacle
(C)
Cherrie Wing Yin Ho
(CWY)
Chi-Fai Ng
(CF)
Chloe Mount
(C)
Chon Meng Lam
(CM)
Chris Blick
(C)
Christian Brown
(C)
Christopher Gallegos
(C)
Claire Higgs
(C)
Clíodhna Browne
(C)
Conor McCann
(C)
Cristina Plaza Alonso
(CP)
Daniel Beder
(D)
Daniel Cohen
(D)
Daniel Gordon
(D)
Daniel Wilby
(D)
Danny Gordon
(D)
David Hua Wu Lau
(DHW)
David Hrouda
(D)
Dávid Karsza
(D)
David Mak
(D)
David Martin-Way
(D)
Denula Suthaharan
(D)
Dhruv Patel
(D)
Diego M Carrion
(DM)
Donald Nyanhongo
(D)
Edward Bass
(E)
Edward Mains
(E)
Edwin Chau
(E)
Elba Canelon Castillo
(EC)
Elizabeth Day
(E)
Elsayed Desouky
(E)
Emily Gaines
(E)
Emma Papworth
(E)
Emrah Yuruk
(E)
Enes Kilic
(E)
Eoin Dinneen
(E)
Erika Palagonia
(E)
Evanguelos Xylinas
(E)
Faizan Khawaja
(F)
Fernando Cimarra
(F)
Florian Bardet
(F)
Francesca Kum
(F)
Francesca Peters
(F)
Gábor Kovács
(G)
Geroge Tanasescu
(G)
Giles Hellawell
(G)
Giovanni Tasso
(G)
Gitte Lam
(G)
Giuseppe La Montagna
(G)
Giuseppe Pizzuto
(G)
Gordan Lenart
(G)
Graeme MacLennan
(G)
Günal Özgür
(G)
Hai Bi
(H)
Hannah Lyons
(H)
Hannah Warren
(H)
Hashim Ahmed
(H)
Helen Simpson
(H)
Helena Burden
(H)
Helena Gresty
(H)
Hernado Rios Pita
(HR)
Holly Clarke
(H)
Hosam Serag
(H)
Howard Kynaston
(H)
Hugh Crawford-Smith
(H)
Hugh Mostafid
(H)
Hugo Otaola-Arca
(H)
Hui Fen Koo
(H)
Ibrahim Ibrahim
(I)
Idir Ouzaid
(I)
Ignacio Puche-Sanz
(I)
Igor Tomašković
(I)
Ilker Tinay
(I)
Iqbal Sahibzada
(I)
Isaac Thangasamy
(I)
Iván Revelo Cadena
(IR)
Jacques Irani
(J)
Jakub Udzik
(J)
James Brittain
(J)
James Catto
(J)
James Green
(J)
James Tweedle
(J)
Jamie Borrego Hernando
(JB)
Jamie Leask
(J)
Jas Kalsi
(J)
Jason Frankel
(J)
Jason Toniolo
(J)
Jay D Raman
(JD)
Jean Courcier
(J)
Jeevan Kumaradeevan
(J)
Jennifer Clark
(J)
Jennifer Jones
(J)
Jeremy Yuen-Chun Teoh
(JY)
John Iacovou
(J)
John Kelly
(J)
John P Selph
(JP)
Jonathan Aning
(J)
Jon Deeks
(J)
Jonathan Olivier
(J)
Jonny Maw
(J)
José Antonio Herranz-Yagüe
(JA)
Jose Ignacio Nolazco
(JI)
Jose Manuel Cózar-Olmo
(JM)
Joseph Bagley
(J)
Joseph Jelski
(J)
Joseph Norris
(J)
Joseph Testa
(J)
Joshua Meeks
(J)
Juan Hernandez
(J)
Juan Luis Vásquez
(JL)
Karen Randhawa
(K)
Karishma Dhera
(K)
Katarzyna Gronostaj
(K)
Kathleen Houlton
(K)
Kathleen Lehman
(K)
Kathryn Gillams
(K)
Kelvin Adasonla
(K)
Kevin Brown
(K)
Kevin Murtagh
(K)
Kiki Mistry
(K)
Kim Davenport
(K)
Kosuke Kitamura
(K)
Laura Derbyshire
(L)
Laurence Clarke
(L)
Lawrie Morton
(L)
Levin Martinez
(L)
Louise Goldsmith
(L)
Louise Paramore
(L)
Luc Cormier
(L)
Lucio Dell'Atti
(L)
Lucy Simmons
(L)
Luis Martinez-Piñeiro
(L)
Luis Rico
(L)
Luke Chan
(L)
Luke Forster
(L)
Lulin Ma
(L)
Madeline Moore
(M)
Maria Camacho Gallego
(MC)
Maria José Freire
(MJ)
Mark Emberton
(M)
Mark Feneley
(M)
Marta Viridiana Muñoz Rivero
(MVM)
Matea Pirša
(M)
Matteo Tallè
(M)
Matthew Crockett
(M)
Matthew Liew
(M)
Matthew Trail
(M)
Meghan Cooper
(M)
Meghana Kulkarni
(M)
Michael Ager
(M)
Ming He
(M)
Mo Li
(M)
Mohamed Omran Breish
(M)
Mohamed Tarin
(M)
Mohammed Aldiwani
(M)
Mudit Matanhelia
(M)
Muhammad Pasha
(M)
Mustafa Kaan Akalın
(MK)
Nasreen Abdullah
(N)
Nathan Hale
(N)
Neha Gadiyar
(N)
Neil Kocher
(N)
Nicholas Bullock
(N)
Nicholas Campain
(N)
Nicola Pavan
(N)
Nihad Al-Ibraheem
(N)
Nikita Bhatt
(N)
Nishant Bedi
(N)
Nitin Shrotri
(N)
Niyati Lobo
(N)
Olga Balderas
(O)
Omar Kouli
(O)
Otakar Capoun
(O)
Pablo Oteo Manjavacas
(PO)
Paolo Gontero
(P)
Paramananthan Mariappan
(P)
Patricio Garcia Marchiñena
(PG)
Paul Erotocritou
(P)
Paul Sweeney
(P)
Paula Planelles
(P)
Peter Acher
(P)
Peter C Black
(PC)
Peter K Osei-Bonsu
(PK)
Peter Østergren
(P)
Peter Smith
(P)
Peter-Paul Michiel Willemse
(PM)
Piotr L Chlosta
(PL)
Qurrat Ul Ain
(Q)
Rachel Barratt
(R)
Rachel Esler
(R)
Raihan Khalid
(R)
Ray Hsu
(R)
Remigiusz Stamirowski
(R)
Reshma Mangat
(R)
Ricardo Cruz
(R)
Ricky Ellis
(R)
Robert Adams
(R)
Robert Hessell
(R)
Robert J A Oomen
(RJA)
Robert McConkey
(R)
Robert Ritchie
(R)
Roberto Jarimba
(R)
Rohit Chahal
(R)
Rosado Mario Andres
(RM)
Rosalyn Hawkins
(R)
Rotimi David
(R)
Rustom P Manecksha
(RP)
Sachin Agrawal
(S)
Syed Sami Hamid
(SS)
Samuel Deem
(S)
Sanchia Goonewardene
(S)
Satchi Kuchibhotla Swami
(SK)
Satoshi Hori
(S)
Shahid Khan
(S)
Shakeel Mohammud Inder
(SM)
Shanthi Sangaralingam
(S)
Shekhar Marathe
(S)
Sheliyan Raveenthiran
(S)
Shigeo Horie
(S)
Shomik Sengupta
(S)
Sian Parson
(S)
Sidney Parker
(S)
Simon Hawlina
(S)
Simon Williams
(S)
Simone Mazzoli
(S)
Slawomir Grzegorz Kata
(SG)
Sofia Pinheiro Lopes
(SP)
Sónia Ramos
(S)
Sonpreet Rai
(S)
Sophie Rintoul-Hoad
(S)
Sorcha O'Meara
(S)
Steve Morris
(S)
Stacey Turner
(S)
Stefano Venturini
(S)
Stephanos Almpanis
(S)
Steven Joniau
(S)
Sunjay Jain
(S)
Susan Mallett
(S)
Sven Nikles
(S)
Shahzad Sylvia Yan
(SS)
Taeweon Lee
(T)
Taha Uçar
(T)
Tamsin Drake
(T)
Tarq Toma
(T)
Teresa Cabañuz Plo
(TC)
Thierry Bonnin
(T)
Tim Muilwijk
(T)
Tim Wollin
(T)
Timothy Shun Man Chu
(TSM)
Timson Appanna
(T)
Tom Brophy
(T)
Tom Ellul
(T)
Tomas Austin
(T)
Tomaž Smrkolj
(T)
Tracey Rowe
(T)
Troy Sukhu
(T)
Trushar Patel
(T)
Tullika Garg
(T)
Turhan Çaşkurlu
(T)
Uros Bele
(U)
Usman Haroon
(U)
Víctor Crespo-Atín
(V)
Victor Parejo Cortes
(VP)
Victoria Capapé Poves
(VC)
Vincent Gnanapragasam
(V)
Vineet Gauhar
(V)
Vinnie During
(V)
Vivek Kumar
(V)
Vojtech Fiala
(V)
Wasim Mahmalji
(W)
Wayne Lam
(W)
Yew Fung Chin
(YF)
Yigit Filtekin
(Y)
Yih Chyn Phan
(YC)
Youssed Ibrahim
(Y)
Zachary A Glaser
(ZA)
Zainal Adwin
(Z)
Zijian Qin
(Z)
Zsuzsanna Zotter
(Z)
Zulkifli Zainuddin
(Z)
Informations de copyright
© 2021 The Authors BJU International published by John Wiley & Sons Ltd on behalf of BJU International.
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