Dengratiols A-D, four new bibenzyl derivatives from Dendrobium gratiossimum.

Antineoplastic Agents, Phytogenic / isolation & purification Bibenzyls / isolation & purification Cell Line, Tumor China Dendrobium / chemistry Humans Molecular Structure Phytochemicals / isolation & purification Plant Stems / chemistry
Bibenzyls Dendrobium gratiossimum Dengratiols Tropolone

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Jul 2021
Historique:
received: 21 02 2021
revised: 30 04 2021
accepted: 30 04 2021
pubmed: 16 5 2021
medline: 16 9 2021
entrez: 15 5 2021
Statut: ppublish

Résumé

Dengratiol A (1), an unprecedented bibenzyl derivative bearing a tropolone unit together with three pairs of bibenzyl enantiomers (±)-dengratiols B-D [(±)-2-(±)-4], were isolated from Dendrobium gratiossimum Rchb.f. The resolution of enantiomers was performed with chiral HPLC. Their structures were characterized by extensive spectroscopic data analysis and calculated electronic circular dichroism (ECD). A hypothetical biosynthetic pathway for 1 is proposed. Biological assay revealed that (-)-2 showed moderate antiviral effect against IAV with IC

Identifiants

DOI: 10.1016/j.fitote.2021.104926 PMID: 33991602
pubmed: 33991602
pii: S0367-326X(21)00101-5
doi: 10.1016/j.fitote.2021.104926
pii:
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Bibenzyls 0
Phytochemicals 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104926

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Jiawei Sun (J)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.

Jimei Liu (J)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.

Yuyu Liu (Y)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.

Ridao Chen (R)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.

Yan Li (Y)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.

Shan Cen (S)

Department of Immunology, Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China.

Xiaomei Chen (X)

Institute of Medicinal Plants, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China.

Shunxing Guo (S)

Institute of Medicinal Plants, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China.

Jungui Dai (J)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China. Electronic address: jgdai@imm.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques d'origine végétale › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Bibenzyles › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Orchidaceae › Dendrobium › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Dengratiols A-D, four new bibenzyl derivatives...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Tiges de plante › Dengratiols A-D, four new bibenzyl derivatives...