Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe

Animals Apolipoproteins E / deficiency Female Interferon Regulatory Factors / deficiency Mice Mice, Inbred C57BL Mice, Knockout Myeloid Cells / metabolism Plaque, Atherosclerotic / metabolism
Anti-inflammation Aortic macrophages Atherosclerosis Interferon regulatory factor 5 Macrophage polarization (M1, M2) Plaque stabilization

Journal

Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730

Informations de publication

Date de publication:
11 2021
Historique:
received: 23 02 2021
revised: 06 05 2021
accepted: 07 05 2021
pubmed: 16 5 2021
medline: 25 3 2022
entrez: 15 5 2021
Statut: ppublish

Résumé

Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize that myeloid cell-specific deletion of IRF5 is protective against atherosclerosis. Female Apoe Myeloid cell-specific Irf5 deficiency blunted LPS/IFNγ-induced inflammatory gene expression in vitro and in the atherosclerotic aorta in vivo. While atherosclerotic lesion size was not reduced in myeloid cell-specific Irf5-deficient Apoe Our study provides genetic evidence that selectively altering macrophage polarization induces a stable plaque phenotype in mice.

Identifiants

DOI: 10.1016/j.molmet.2021.101250 PMID: 33991749 PMC: PMC8178123
pubmed: 33991749
pii: S2212-8778(21)00095-8
doi: 10.1016/j.molmet.2021.101250
pmc: PMC8178123
pii:
doi:

Substances chimiques

Apoe protein, mouse 0
Apolipoproteins E 0
Interferon Regulatory Factors 0
Irf5 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101250

Subventions

Organisme : NHLBI NIH HHS
ID : R35 HL145241
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.

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Auteurs

Julia Leipner (J)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: julia.leipner@universitaets-herzzentrum.de.

Tsai-Sang Dederichs (TS)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: tsai-sang.dederichs@uniklinik-freiburg.de.

Alexander von Ehr (A)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: alexander.von.ehr@uniklinik-freiburg.de.

Simon Rauterberg (S)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: simon.rauterberg@uniklinik-freiburg.de.

Carolin Ehlert (C)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: carolin.ehlert@universitaets-herzzentrum.de.

Julian Merz (J)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: Julian.merz@universitaets-herzzentrum.de.

Bianca Dufner (B)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: bianca.dufner@universitaets-herzzentrum.de.

Natalie Hoppe (N)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: natalie.hoppe@universitaets-herzzentrum.de.

Katja Krebs (K)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: katja.krebs@uniklinik-freiburg.de.

Timo Heidt (T)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: timo.heidt@universitaets-herzzentrum.de.

Constantin von Zur Muehlen (C)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: constantin.vonzurmuehlen@universitaets-herzzentrum.de.

Peter Stachon (P)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: peter.stachon@universitaets-herzzentrum.de.

Klaus Ley (K)

La Jolla Institute for Allergy & Immunology, Division of Inflammation Biology, 9420 Athena Circle, La Jolla, CA, 92037, USA. Electronic address: klaus@liai.org.

Dennis Wolf (D)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: dennis.wolf@universitaets-herzzentrum.de.

Andreas Zirlik (A)

LKH-University Hospital Graz, Department of Cardiology, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: andreas.zirlik@medunigraz.at.

Christoph Bode (C)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: christoph.bode@universitaets-herzzentrum.de.

Ingo Hilgendorf (I)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: ingo.hilgendorf@universitaets-herzzentrum.de.

Carmen Härdtner (C)

University Heart Center, Department of Cardiology and Angiology I, University of Freiburg and Faculty of Medicine, 55 Hugstetter St, 79106, Freiburg, Germany. Electronic address: carmen.haerdtner@universitaets-herzzentrum.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Myeloid cell-specific Irf5 deficiency...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Myeloid cell-specific Irf5 deficiency...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Myeloid cell-specific Irf5 deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Myeloid cell-specific Irf5 deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Myeloid cell-specific Irf5 deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Myeloid cell-specific Irf5 deficiency...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Myeloid cell-specific Irf5 deficiency...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Myeloid cell-specific Irf5 deficiency...