Production and isolation of pharmaceutical drug nanoparticles.
Active pharmaceutical ingredients
Bioavailability
Bottom-up methods
Nanoparticle isolation
Nanoparticle stabilisation
Nanoparticles
Top-down methods
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
15 Jun 2021
15 Jun 2021
Historique:
received:
14
03
2021
revised:
08
05
2021
accepted:
11
05
2021
pubmed:
17
5
2021
medline:
22
6
2021
entrez:
16
5
2021
Statut:
ppublish
Résumé
Nanosizing of pharmaceutical drug particles is one of the most important drug delivery platforms approaches for the commercial development of poorly water-soluble drug molecules. Though nanosizing of drug particles has been proven to greatly enhance drugs dissolution rate and apparent solubility, nanosized materials have presented significant challenges for their formulation as solid dosage forms (e.g. tablets, capsules). This is due to the strong Van der Waals attraction forces between dry nanoparticles leading to aggregation, cohesion, and consequently poor flowability. In this review, the broad area of nanomedicines is overviewed with the primary focus on drug nanocrystals and the top-down and bottom-up methods used in their fabrication. The review also looks at how nanosuspensions of pharmaceutical drugs are generated and stabilised, followed by subsequent strategies for isolation of the nanoparticles. A perspective on the future outlook for drug nanocrystals is also presented.
Identifiants
pubmed: 33992712
pii: S0378-5173(21)00513-5
doi: 10.1016/j.ijpharm.2021.120708
pii:
doi:
Substances chimiques
Pharmaceutical Preparations
0
Tablets
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120708Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.