The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis.
B-catenin
Colorectal cancer
Disease free survival
Meta-analysis
Overall survival
Systematic Review
cancer specific cancer
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
08
12
2020
revised:
23
03
2021
accepted:
31
03
2021
pubmed:
17
5
2021
medline:
14
7
2021
entrez:
16
5
2021
Statut:
ppublish
Résumé
β-catenin is a key component of Wnt signalling, which plays a crucial role in CRC progression. Therefore, a meta-analysis was performed to assess the prognostic value of β-catenin expression in CRC patients. PubMed and Web of Science were searched for relevant publications referring to the association between β-catenin expression and outcome of CRC patients. Review Manager version 5.4 was employed to analysis data from 28 eligible studies (containing 5475 patients). Of these, 6 provided data on DFS, 6 provided data on CSS and 18 reports provided data on OS. High nuclear β-catenin expression was significantly associated with poorer DFS, CSS and OS in patients with CRC whereas, low membranous β-catenin expression was associated to poor OS. In conclusion, β-catenin has prognostic value and potential as a biomarker to stratify patients with CRC. However, further work with high quantity tissue cohorts and patient data is required to confirm this conclusion.
Identifiants
pubmed: 33992802
pii: S1040-8428(21)00125-6
doi: 10.1016/j.critrevonc.2021.103337
pii:
doi:
Substances chimiques
beta Catenin
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103337Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.