Effects of analgesic and surgical modality on immune response in colorectal cancer surgery.
Administration, Intravenous
Adult
Aged
Aged, 80 and over
Analgesia, Epidural
/ methods
Analgesics
/ administration & dosage
Colorectal Neoplasms
/ immunology
Colorectal Surgery
/ methods
Female
Follow-Up Studies
Humans
Immunity
Laparoscopy
/ methods
Length of Stay
/ statistics & numerical data
Male
Middle Aged
Prognosis
Prospective Studies
Analgesia
Inflammation
Interleukin-10
Laparoscopic surgery
Mast cell
Open surgery
Tumor necrosis factor
Journal
Surgical oncology
ISSN: 1879-3320
Titre abrégé: Surg Oncol
Pays: Netherlands
ID NLM: 9208188
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
22
09
2020
revised:
10
04
2021
accepted:
04
05
2021
pubmed:
17
5
2021
medline:
18
1
2022
entrez:
16
5
2021
Statut:
ppublish
Résumé
Different surgical methods, anesthesia, and analgesia are known to modify the surgical stress response, especially in patients with malignancy. We compared the impact of patient-controlled intravenous (PCA) versus epidural analgesia (EDA) on tumor-related mucosal immune response in patients undergoing open or laparoscopic surgery for colorectal cancer. In a University Hospital subgroup (n = 43) of a larger cohort (n = 235) of patients undergoing open or laparoscopic surgery for colorectal carcinoma randomized to PCA or EDA, colorectal tissues were stained for interleukin-10 (IL-10), tumor necrosis factor (TNF), and mast cell tryptase and then examined by immunofluorescence microscopy. More IL-10 The surgical method, rather than type of analgesia, may have higher impact on peri-operative inflammation. Laparoscopic surgery when combined with EDA for colorectal cancer caused a decrease in the TNF and IL-10 expression and mast cells. EDA seems to have an anti-inflammatory effect on cancer-related inflammation during open surgery.
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
Different surgical methods, anesthesia, and analgesia are known to modify the surgical stress response, especially in patients with malignancy. We compared the impact of patient-controlled intravenous (PCA) versus epidural analgesia (EDA) on tumor-related mucosal immune response in patients undergoing open or laparoscopic surgery for colorectal cancer.
METHODS
METHODS
In a University Hospital subgroup (n = 43) of a larger cohort (n = 235) of patients undergoing open or laparoscopic surgery for colorectal carcinoma randomized to PCA or EDA, colorectal tissues were stained for interleukin-10 (IL-10), tumor necrosis factor (TNF), and mast cell tryptase and then examined by immunofluorescence microscopy.
RESULTS
RESULTS
More IL-10
CONCLUSIONS
CONCLUSIONS
The surgical method, rather than type of analgesia, may have higher impact on peri-operative inflammation. Laparoscopic surgery when combined with EDA for colorectal cancer caused a decrease in the TNF and IL-10 expression and mast cells. EDA seems to have an anti-inflammatory effect on cancer-related inflammation during open surgery.
Identifiants
pubmed: 33992897
pii: S0960-7404(21)00091-8
doi: 10.1016/j.suronc.2021.101602
pii:
doi:
Substances chimiques
Analgesics
0
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
101602Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.