PdCl

Animals Anti-Inflammatory Agents / chemical synthesis Arthritis, Experimental / drug therapy Catalysis Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism Embryo, Nonmammalian / drug effects Female Isocoumarins / chemical synthesis Knee Joint / drug effects Male Mice Molecular Docking Simulation Molecular Structure Palladium / chemistry Phosphodiesterase 4 Inhibitors / chemical synthesis Protein Binding RAW 264.7 Cells Rats, Wistar Structure-Activity Relationship Sulfonamides / chemical synthesis Zebrafish
Inflammation Isocoumarin PDE-4 Pd-catalyst Zebrafish

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Oct 2021
Historique:
received: 19 03 2021
revised: 22 04 2021
accepted: 28 04 2021
pubmed: 17 5 2021
medline: 23 6 2021
entrez: 16 5 2021
Statut: ppublish

Résumé

While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfonyl/aminocarboxamide moiety to the C-3 benzene ring attached to the isocoumarin framework. This new class of isocoumarins were synthesized via a PdCl

Identifiants

DOI: 10.1016/j.ejmech.2021.113514 PMID: 33992926
pubmed: 33992926
pii: S0223-5234(21)00363-9
doi: 10.1016/j.ejmech.2021.113514
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Isocoumarins 0
Phosphodiesterase 4 Inhibitors 0
Sulfonamides 0
Palladium 5TWQ1V240M
Cyclic Nucleotide Phosphodiesterases, Type 4 EC 3.1.4.17
palladium chloride N9214IR8N7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113514

Informations de copyright

Copyright © 2021 Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

B Thirupataiah (B)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India; Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

Guntipally Mounika (G)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India.

Gangireddy Sujeevan Reddy (GS)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India; Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

Jetta Sandeep Kumar (JS)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India; Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

Kazi Amirul Hossain (KA)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India.

Raghavender Medishetti (R)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India; Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

Snigdha Samarpita (S)

Immunopathology Lab, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, India.

Mahaboobkhan Rasool (M)

Immunopathology Lab, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, India.

Jayesh Mudgal (J)

Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

Jessy E Mathew (JE)

Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

Gautham G Shenoy (GG)

Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

C Mallikarjuna Rao (CM)

Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, 576 104, Karnataka, India.

Kiranam Chatti (K)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India.

Kishore V L Parsa (KVL)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India.

Manojit Pal (M)

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India. Electronic address: manojitpal@rediffmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PdCl
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › PdCl
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Arthrite expérimentale › PdCl
questionsmedicales.fr › Phénomènes chimiques › Catalyse › PdCl
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › 3',5'-Cyclic-AMP Phosphodiesterases › Cyclic Nucleotide Phosphodiesterases, Type 4 › PdCl
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › PdCl
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › Isocoumarines › PdCl
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Articulation du genou › PdCl
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PdCl
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › PdCl
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › PdCl
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Palladium › PdCl
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la phosphodiestérase › Inhibiteurs de la phosphodiestérase-4 › PdCl
questionsmedicales.fr › Métabolisme › Liaison aux protéines › PdCl
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › PdCl
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › PdCl
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › PdCl
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › PdCl
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › PdCl