Characterization of combined intracavitary/interstitial brachytherapy including oblique needles in locally advanced cervix cancer.
Cervix cancer
Intracavitary and interstitial brachytherapy
MR-guided adaptive brachytherapy
Parallel and oblique needles
Journal
Brachytherapy
ISSN: 1873-1449
Titre abrégé: Brachytherapy
Pays: United States
ID NLM: 101137600
Informations de publication
Date de publication:
Historique:
received:
12
01
2021
revised:
24
03
2021
accepted:
28
03
2021
pubmed:
18
5
2021
medline:
12
10
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
To characterize and report on dosimetric outcomes of image guided adaptive brachytherapy (IGABT) using intracavitary and interstitial (IC/IS) applicators including oblique needles (O-needles) in locally advanced cervical cancer (LACC). Twenty LACC patients treated with radio-chemotherapy and offered IC/IS-IGABT including O-needles were analyzed. An in-house 3D-printed vaginal template was used to steer the needles parallel and obliquely in relation to the tandem, supplemented with free-hand needles if needed. Implant characteristics and loading patterns were analyzed. Using the equivalent dose in 2Gy-fractions (EQD2) concept, cumulative (EBRT+BT) V85, V75, V60Gy, targets/OARs doses and high dose volumes (150%, 200% and 300% (100% = 85 Gy EQD2 Median(range) tumor width at diagnosis was 5.5(3.6; 7.5)cm; CTV The use of O-needles in patients with large and/or unfavorable tumors resulted in excellent target coverage and OARs sparing. Intrauterine and vaginal loadings were reduced compared to standard loading and almost half of the loading was shifted into IS needles. This was achieved with gentle loading in the majority of dwell positions.
Identifiants
pubmed: 33994344
pii: S1538-4721(21)00089-1
doi: 10.1016/j.brachy.2021.03.019
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
796-806Informations de copyright
Copyright © 2021 American Brachytherapy Society. All rights reserved.