Neuronal Representation of Locomotion During Motivated Behavior in the Mouse Anterior Cingulate Cortex.
goal-directed behavior
locomotion
motor control
mouse model
prefrontal cortex
reward
Journal
Frontiers in systems neuroscience
ISSN: 1662-5137
Titre abrégé: Front Syst Neurosci
Pays: Switzerland
ID NLM: 101477946
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
01
2021
accepted:
26
02
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
The anterior cingulate cortex (ACC) is located within the dorsomedial prefrontal cortex (PFC), and processes and facilitates goal-directed behaviors relating to emotion, reward, and motor control. However, it is unclear how ACC neurons dynamically encode motivated behavior during locomotion. In this study, we examined how information for locomotion and behavioral outcomes is temporally represented by individual and ensembles of ACC neurons in mice during a self-paced locomotor reward-based task. By recording and analyzing the activity of ACC neurons with a microdrive tetrode array while the mouse performed the locomotor task, we found that more than two-fifths of the neurons showed phasic activity relating to locomotion or the reward behavior. Some of these neurons showed significant differences in their firing rate depending on the behavioral outcome. Furthermore, by applying a demixed principal component analysis, the ACC population activity was decomposed into components representing locomotion and the previous/future outcome. These results indicated that ACC neurons dynamically integrate motor and behavioral inputs during goal-directed behaviors.
Identifiants
pubmed: 33994964
doi: 10.3389/fnsys.2021.655110
pmc: PMC8116624
doi:
Types de publication
Journal Article
Langues
eng
Pagination
655110Informations de copyright
Copyright © 2021 Sachuriga, Nishimaru, Takamura, Matsumoto, Ferreira Pereira de Araújo, Ono and Nishijo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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