Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake.
food intake
metabolic homeostasis
obesity
orexigen and anorexigen neurons
purinergic receptors
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
01
2021
accepted:
09
04
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.
Identifiants
pubmed: 33995077
doi: 10.3389/fphar.2021.655989
pii: 655989
pmc: PMC8117016
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
655989Informations de copyright
Copyright © 2021 Caruso, Zuccarini, Di Iorio, Muhammad and Ronci.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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