Role of Tonsillar Chronic Inflammation and Commensal Bacteria in the Pathogenesis of Pediatric OSA.
Adolescent
B-Lymphocytes
/ immunology
Bacteria
/ immunology
Bacterial Infections
/ immunology
Cells, Cultured
Child
Child, Preschool
Chronic Disease
Cohort Studies
Cytokines
/ metabolism
Female
Germinal Center
/ immunology
Humans
Hypertrophy
/ immunology
Inflammation
/ immunology
Male
Mouth Mucosa
/ immunology
Palatine Tonsil
/ immunology
Sleep Apnea, Obstructive
/ complications
T-Lymphocytes
/ immunology
Tonsillectomy
Tonsillitis
/ complications
apnea
mucosal immunity
obstructive
oral bacteria
sleep
tonsils
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
12
2020
accepted:
06
04
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
7
10
2021
Statut:
epublish
Résumé
Immune responses at the boundary between the host and the world beyond are complex and mucosal tissue homeostasis relies on them. Obstructive sleep apnea (OSA) is a syndrome suffered by children with hypertrophied tonsils. We have previously demonstrated that these tonsils present a defective regulatory B cell (Breg) compartment. Here, we extend those findings by uncovering the crucial role of resident pro-inflammatory B and T cells in sustaining tonsillar hypertrophy and hyperplasia by producing TNFα and IL17, respectively, in
Identifiants
pubmed: 33995367
doi: 10.3389/fimmu.2021.648064
pmc: PMC8116894
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
648064Informations de copyright
Copyright © 2021 Sarmiento Varón, De Rosa, Rodriguez, Fernández, Billordo, Baz, Beccaglia, Spada, Mendoza, Barberis, Vay, Arabolaza, Paoli and Arana.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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