Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage.
RNA sequencing
human blood
long non-coding RNA
periventricular white matter damage
premature infants
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
12
2020
accepted:
29
03
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
Long non-coding RNA (LncRNA) has high expression in the brain. Animal studies have shown that lncRNA plays an important role in brain functions and mediates the development of many neurological diseases. However, data on the expression of lncRNAs and the clinical significance in prematurely born infants with diseases such as periventricular white matter damage (PWMD) remains scant. Here, we compared the expression of the lncRNAs in whole blood samples obtained from prematurely born infants with PWMD with samples from prematurely born infants without PWMD. Our data demonstrated differential expression of the lncRNAs between the two groups. Further, we showed that the lncRNAs play important roles in the development of PWMD. Our findings give insights into the functions of the lncRNAs in PWMD and provide evidence for the improvement of diagnostic and treatment strategies in infants with PWMD.
Identifiants
pubmed: 33995480
doi: 10.3389/fgene.2021.641526
pmc: PMC8120246
doi:
Types de publication
Journal Article
Langues
eng
Pagination
641526Informations de copyright
Copyright © 2021 Wang, Liu, Liao, Qiao, Zhu, Wu, Zhou, Zhang, Li, Lin, Ma, Gu and Shu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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