Improved Odor Identification Ability and Increased Regional Gray Matter Volume After Olfactory Training in Patients With Idiopathic Olfactory Loss.
gray matter volume
idiopathic olfactory loss
odor identification
olfactory training
severity of olfactory loss
Journal
i-Perception
ISSN: 2041-6695
Titre abrégé: Iperception
Pays: United States
ID NLM: 101574031
Informations de publication
Date de publication:
Historique:
received:
28
05
2020
accepted:
09
03
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
Idiopathic olfactory loss (IOL) is thought as an early marker for neurodegenerative disease. This study investigated the effect of olfactory training (OT) on regional gray matter volume (GMV) among patients with IOL. A total of 24 patients (mean age 64.6 years, 11 male) with IOL and 30 control participants with normal olfaction (mean age 62.6 years, 13 males) were included in the study. Voxel-based morphometry was performed to compare the GMV between patient and control groups. Only the patients received OT (averaged duration 7 months), and a longitudinal approach was used to examine the GMV change from pre- to post-OT. Moreover, the effect of OT on GMV change was explored for patients with different severity of olfactory loss (anosmia vs. hyposmia). Olfactory performance was measured alongside using the "Sniffin' Sticks." Patients had improved odor identification and larger GMV in the bilateral cerebellum, bilateral thalamus, left precentral gyrus, right gyrus rectus, and medial orbitofrontal cortex after OT. However, no correlation was found between changes of odor identification and increased regional GMV. Besides, patients with anosmia, compared with patient with hyposmia, demonstrated increased GMV in the left precuneus, left superior frontal medial cortex, and left midcingulate cortex after OT. The study showed improved odor identification ability among patients with IOL after OT, which is unlikely related to spontaneous recovery. In this specific patient group, the GMV alterations may be associated with factors not directly predicted by the currently performed measurements, but possibly higher order olfactory-related functional changes.
Identifiants
pubmed: 33996020
doi: 10.1177/20416695211005811
pii: 10.1177_20416695211005811
pmc: PMC8073728
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20416695211005811Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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