Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis.
Malignant transformation
Oral squamous cell carcinoma
Oral submucous fibrosis
Predictive biomarker
Journal
Journal of oral biology and craniofacial research
ISSN: 2212-4268
Titre abrégé: J Oral Biol Craniofac Res
Pays: Netherlands
ID NLM: 101619156
Informations de publication
Date de publication:
Historique:
received:
21
02
2021
revised:
10
03
2021
accepted:
18
03
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
ppublish
Résumé
Histo-morphological alterations observed at mucosal surgical margins can be envisaged as potential markers of malignant transformation. In this paper, we have presented a very striking observation at the mucosal surgical margins of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSMF). Out of 38 cases of OSCC-OSMF, 22 (57.89%) showed conspicuous large dilated vascular spaces lined by endothelial cells in the background of dense fibrosis. These large dilated areas were engorged with red blood cells and were located at the juxta-epithelial and submucosal regions. Since surgical margin tissues are biologically close to malignant transformation, we proposed this unique feature as a potential predictive marker for oral submucous fibrosis that will aid in the early detection of OSCC. Future cohort studies are warranted to prove the authenticity of the present observations.
Identifiants
pubmed: 33996430
doi: 10.1016/j.jobcr.2021.03.007
pii: S2212-4268(21)00038-5
pmc: PMC8093929
doi:
Types de publication
Journal Article
Langues
eng
Pagination
365-367Informations de copyright
© 2021 Craniofacial Research Foundation. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
All the authors associated with the present manuscript declared no potential conflict of interest with respect to the research, authorship, and/or publication of this article.
Références
Oral Oncol. 2018 Mar;78:218-219
pubmed: 29428570
J Oral Pathol Med. 2018 Apr;47(4):410-416
pubmed: 29478271
J Oral Pathol Med. 2017 Jul;46(6):448-453
pubmed: 28129456
J Oral Pathol Med. 2017 Apr;46(4):246-252
pubmed: 27560394
J Investig Clin Dent. 2019 Nov;10(4):e12443
pubmed: 31325233
Cell. 2017 Feb 9;168(4):657-669
pubmed: 28187287
J Oral Pathol Med. 2019 Apr;48(4):321-325
pubmed: 30715767
J Oral Pathol Med. 2018 Jul;47(6):627-628
pubmed: 29656454