Amyloid arthropathy in smoldering myeloma: Do not take it lightly.
Amyloidosis
Arthrocentesis
Arthropathic
Congo red
Journal
Leukemia research reports
ISSN: 2213-0489
Titre abrégé: Leuk Res Rep
Pays: England
ID NLM: 101608906
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
03
2021
revised:
09
04
2021
accepted:
21
04
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
We report a case of smoldering multiple myeloma patient who developed signs and symptoms consistent with polyarthritis. A PET-CT demonstrated marked FDG activity in multiple joints, concerning for inflammatory arthritis. Arthrocentesis from the glenohumeral joint was consistent with inflammatory synovial fluid with no evidence for infection or crystals. Congo-red stain of the synovial fluid was positive, and mass-spectrometry based amyloid typing was consistent with wild-type transthyretin type. The patient responded instantly to glucocorticoids. This case reports highlights the feasibility of non-tissue diagnosis of amyloidosis using body fluids and underscores the importance of accurate typing to avoid erroneous treatment.
Identifiants
pubmed: 33996437
doi: 10.1016/j.lrr.2021.100242
pii: S2213-0489(21)00009-1
pmc: PMC8105656
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100242Subventions
Organisme : NCI NIH HHS
ID : P50 CA186781
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 The Authors. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
AD reports scientific board advisory participation for Alnylam, Intellia and Janssen and grants from Takeda, Pfizer, Prothena, Celgene, Alnylam and Janssen. MAG reports consultancy for Millennium Pharmaceuticals and received honoraria from Celgene, Millennium Pharmaceuticals, Onyx Pharmaceuticals, Novartis, GlaxoSmithKline, Prothena, Ionis Pharmaceuticals, and Amgen. The remaining authors declare no competing financial interests.
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