Treatment of clinical stage I non-seminoma.
Active surveillance
Germ cell tumors
Non-seminomatous germ cell tumors
Retroperitoneal lymph node dissection
Journal
Asian journal of urology
ISSN: 2214-3882
Titre abrégé: Asian J Urol
Pays: Singapore
ID NLM: 101699720
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
07
11
2019
revised:
26
06
2020
accepted:
30
11
2020
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
ppublish
Résumé
Germ cell cancers are the most common solid tumors among men between 15 and 40 years. Non-seminomatous germ cell tumors (NSGCTs) represent a unique and exclusive cohort of germ cell tumor patients. Non-seminoma can harbor different histologic components. The most commonly found histologies are embryonal cell cancer, teratoma, yolk sack tumor and choriocarcinoma, as well as teratocarcinoma and seminoma, in combination with non-seminomatous germ cell tumors histologic types. The clinical definition of stage I non-seminoma is the absence of metastatic lesions on imaging and normal tumor markers. The cure rate for clinical stage I NSGCT is 99% and this can be achieved by three therapeutic strategies: Active surveillance with treatment at the time of relapse, retroperitoneal lymph node dissection or adjuvant chemotherapy. The balancing of these various strategies should always be based on an individual risk profile of NGSCG patient depending on the lymphovascular invasion of the tumor.
Identifiants
pubmed: 33996471
doi: 10.1016/j.ajur.2021.03.001
pii: S2214-3882(21)00004-7
pmc: PMC8099697
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
161-169Informations de copyright
© 2021 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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