Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy.
DNA damage
FLASH
apoptosis
autophagy
cancer stem cell
lysosome
necrosis
ultra-high dose rate irradiation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
02
2021
accepted:
06
04
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
Cancer stem cell (CSC) is thought to be the major cause of radio-resistance and relapse post radiotherapy (RT). Recently ultra-high dose rate "FLASH-RT" evokes great interest for its decreasing normal tissue damages while maintaining tumor responses compared with conventional dose rate RT. However, the killing effect and mechanism of FLASH irradiation (FLASH-IR) on CSC and normal cancer cell are still unclear. Presently the radiation induced death profile of CSC and normal cancer cell were studied. Cells were irradiated with FLASH-IR (∼10
Identifiants
pubmed: 33996830
doi: 10.3389/fcell.2021.672693
pmc: PMC8116574
doi:
Types de publication
Journal Article
Langues
eng
Pagination
672693Informations de copyright
Copyright © 2021 Yang, Lu, Mei, Sun, Han, Qian, Liang, Pan, Kong, Xu, Liu, Gao, Qi, Shou, Chen, Cao, Zhao, Lin, Zhao, Geng, Ma and Yan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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