miR-21a inhibits decidual cell apoptosis by targeting Pdcd4.
Decidual cells
Embryo implantation
Pdcd4
hsa-miR-21
mmu-miR-21a
Journal
Genes & diseases
ISSN: 2352-3042
Titre abrégé: Genes Dis
Pays: Netherlands
ID NLM: 101635967
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
29
07
2019
revised:
18
09
2019
accepted:
27
09
2019
entrez:
17
5
2021
pubmed:
5
10
2019
medline:
5
10
2019
Statut:
epublish
Résumé
Decidualization of endometrial stromal cells (ESCs) accompanied with embryo implantation is a key process in mammalian reproduction. Evidence suggests that maintenance of decidual cells function is essential. As a critical part in post-transcriptional gene regulation, microRNAs (miRNAs/miR) have been confirmed to be involved in decidualization. However, whether microRNAs regulate decidual cells function has not been reported. Aiming to clarify the role and potential mechanism of miRNAs in decidual cells, artificial induced decidualization model in mice was established. There are 94 differentially expressed miRNAs (≥two-fold change) between decidualized and non-decidualized tissues, including 60 upregulated and 34 downregulated miRNAs. Of the differentially expressed miRNAs, mmu-miR-21a is up-regulated. RT-qPCR also confirmed the up-regulation of mmu-miR-21a following decidualization
Identifiants
pubmed: 33997164
doi: 10.1016/j.gendis.2019.09.013
pii: S2352-3042(19)30085-6
pmc: PMC8099688
doi:
Types de publication
Journal Article
Langues
eng
Pagination
171-180Informations de copyright
© 2019 Chongqing Medical University. Production and hosting by Elsevier B.V.
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