The regulatory roles of aquaporins in the digestive system.
Aquaporins
Digestive system
Distribution
Function
Water transfer
Journal
Genes & diseases
ISSN: 2352-3042
Titre abrégé: Genes Dis
Pays: Netherlands
ID NLM: 101635967
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
25
10
2019
revised:
15
12
2019
accepted:
31
12
2019
entrez:
17
5
2021
pubmed:
8
1
2020
medline:
8
1
2020
Statut:
epublish
Résumé
Aquaporins (AQPs) are highly conserved small transmembrane proteins, which are responsible for the water transport across the cell membrane. AQPs are abundantly expressed in numerous types of cells such as epithelial and endothelial cells. The expression of AQP-1, -3, -4, -5, -8 and -9 were found in the digestive system, where these six AQP isoforms serve essential roles including mediating the transmembrane water transport and regulating the secretion of gastrointestinal (GI) fluids, consequently facilitating the digestion and absorption of GI contents. In addition, the expression levels of AQPs are controlled by various factors, and AQPs can stimulate numerous signaling pathways; however, aberrant expression of AQPs in the GI tracts are associated with the initiation and development of numerous diseases. Thus, this review provides an overview of the expression and functions of AQPs in the digestive system.
Identifiants
pubmed: 33997172
doi: 10.1016/j.gendis.2019.12.011
pii: S2352-3042(20)30005-2
pmc: PMC8093583
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
250-258Informations de copyright
© 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare no conflict of interests.
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