Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating
biodistribution
drug delivery
fractional occupancy
in vivo
nanomedicine
Journal
Advanced therapeutics
ISSN: 2366-3987
Titre abrégé: Adv Ther (Weinh)
Pays: Germany
ID NLM: 101724632
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
ppublish
Résumé
Nanoencapsulated drug delivery to solid tumors is a promising approach to overcome pharmacokinetic limitations of therapeutic drugs. However, encapsulation leads to complex drug biodistribution and delivery making analysis of delivery efficacy challenging. As proxies, nanocarrier accumulation or total tumor drug uptake in the tumor are used to evaluate delivery. Yet, these measurements fail to assess delivery of active, released drug to the target, and thus it commonly remains unknown if drug-target occupancy has been achieved. Here, we develop an approach to evaluate the delivery of encapsulated drug to the target, where residual drug target vacancy is measured using a fluorescent drug analog.
Identifiants
pubmed: 33997266
doi: 10.1002/adtp.202000125
pmc: PMC8114878
mid: NIHMS1656595
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R00 CA198857
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA241179
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA079443
Pays : United States
Déclaration de conflit d'intérêts
Competing interests: The authors declare no competing interests.
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