3D Printed Zn-doped Mesoporous Silica-incorporated Poly-L-lactic Acid Scaffolds for Bone Repair.
Bone repair
Poly-L-lactic acid
Zinc doped mesoporous silica
Journal
International journal of bioprinting
ISSN: 2424-8002
Titre abrégé: Int J Bioprint
Pays: Singapore
ID NLM: 101709763
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
01
2021
accepted:
15
02
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
Poly-L-lactic acid (PLLA) lacks osteogenic activity, which limits its application in bone repair. Zinc (Zn) is widely applied to strengthen the biological properties of polymers due to its excellent osteogenic activity. In the present study, Zn-doped mesoporous silica (Zn-MS) particles were synthesized by one-pot hydrothermal method. Then, the particles were induced into PLLA scaffolds prepared by selective laser sintering technique, aiming to improve their osteogenic activity. Our results showed that the synthesized particles possessed rosette-like morphology and uniform mesoporous structure, and the composite scaffold displayed the sustained release of Zn ion in a low concentration range, which was attributed to the shield effect of the PLLA matrix and the strong bonding interaction of Si-O-Zn. The scaffold could evidently promote osteogenesis differentiation of mouse bone marrow mesenchymal stem cells by upregulating their osteogenesis-related gene expression. Besides, Zn-MS particles could significantly increase the compressive strength of the PLLA scaffold because of their rosette-like morphology and mesoporous structure, which can form micromechanical interlocking with the PLLA matrix. The Zn-MS particles possess great potential to improve various polymer scaffold properties due to their advantageous morphology and physicochemical properties.
Identifiants
pubmed: 33997435
doi: 10.18063/ijb.v7i2.346
pii: IJB-7-2-346
pmc: PMC8114096
doi:
Types de publication
Journal Article
Langues
eng
Pagination
346Informations de copyright
Copyright: © 2021 Qian, et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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