Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization.
Biomaterials
Drug delivery systems
Macrophage polarization
Musculoskeletal system soft tissue
Regenerative medicine
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
08
02
2021
revised:
27
03
2021
accepted:
12
04
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in musculoskeletal systems remains a challenge for researchers and surgeons, requiring the application of tissue engineering biomaterials. Successful application depends on the response of the host tissue to the biomaterial and specific healing process of each anatomical structure. The commonly-held view is that biomaterials should be biocompatible to minimize local host immune response. However, a growing number of studies have shown that active modulation of the immune cells, particularly macrophages, via biomaterials is an effective way to control immune response and promote tissue regeneration as well as biomaterial integration. Therefore, we critically review the role of macrophages in the repair of injured musculoskeletal system soft tissues, which have relatively poor regenerative capacities, as well as discuss further enhancement of target tissue regeneration via modulation of macrophage polarization by biomaterial-mediated immunomodulation (biomaterial properties and delivery systems). This active regulation approach rather than passive-evade strategy maximizes the potential of biomaterials to promote musculoskeletal system soft tissue regeneration and provides alternative therapeutic options for repairing critical-sized defects.
Identifiants
pubmed: 33997496
doi: 10.1016/j.bioactmat.2021.04.017
pii: S2452-199X(21)00186-9
pmc: PMC8091177
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4096-4109Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
None.
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