Elevated Serum Lactate in Patients With Lymphoma: It Is Not Always Infection.
ATP, adenosine triphosphate
CT, computed tomography
CoA, coenzyme A
DLBCL, diffuse large B-cell lymphoma
GLUT, facilitative glucose transporter
HR, hazard ratio
IQR, interquartile range
LDH, lactate dehydrogenase
MCT, monocarboxylate transporter
NAD, nicotinamide adenine dinucleotide
NADH, nicotinamide adenine dinucleotide and hydrogen
NHL, non-Hodgkin lymphoma
O2, oxygen
OS, overall survival
TCA, tricarboxylic acid
ULN, upper limit of normal
Journal
Mayo Clinic proceedings. Innovations, quality & outcomes
ISSN: 2542-4548
Titre abrégé: Mayo Clin Proc Innov Qual Outcomes
Pays: Netherlands
ID NLM: 101728275
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
To distinguish between sepsis only vs progressive lymphoma in patients with a history of lymphoma who present to the hospital with lactic acidosis. We identified patients with non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma from January 2014 to December 2015. Patients were categorized into 2 groups: sepsis only or progressive lymphoma. Two-sided Wilcoxon rank sum test and χ A total of 51 patients were identified; 33 (65%) patients were categorized into the sepsis only group, and 18 (35%), into the progressive lymphoma group. Values for serum lactate dehydrogenase (LDH) drawn during hospitalization were statistically different between the sepsis only and progressive lymphoma groups (median, 262 vs 665 U/L; Serum LDH levels used in conjunction with serial serum lactate values may be reliable markers to differentiate patients with progressive lymphomatous disease from patients with lymphoma with sepsis only. The LDH levels should be obtained in all patients with lymphoma who present to the hospital with lactic acidosis.
Identifiants
pubmed: 33997638
doi: 10.1016/j.mayocpiqo.2021.01.012
pii: S2542-4548(21)00031-X
pmc: PMC8105511
doi:
Types de publication
Journal Article
Langues
eng
Pagination
423-430Subventions
Organisme : NCI NIH HHS
ID : P50 CA097274
Pays : United States
Informations de copyright
© 2021 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.
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