Keep the fate: how chromatin regulators safeguard embryonic stem cell identity.
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
received:
08
04
2021
accepted:
19
04
2021
pubmed:
18
5
2021
medline:
6
11
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
Segregation of cells that form the embryo from those that produce the surrounding extra-embryonic tissues is critical for early mammalian development, but the regulatory layers governing these first cell fate decisions remain poorly understood. Recent work in The EMBO Journal identifies two chromatin regulators, Hdac3 and Dax1, that synergistically restrict the developmental potential of mouse embryonic stem cells and act as a lineage barrier to primitive endoderm formation.
Identifiants
pubmed: 33998023
doi: 10.15252/embj.2021108437
pmc: PMC8204858
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e108437Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2021 The Authors.
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