Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
endoplasmic reticulum
engineered heart tissue
human-induced pluripotent stem cells
mitochondria
phospholamban p.Arg14del
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
revised:
31
03
2021
received:
07
07
2020
accepted:
07
04
2021
pubmed:
18
5
2021
medline:
26
10
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
The phospholamban (PLN) p.Arg14del mutation causes dilated cardiomyopathy, with the molecular disease mechanisms incompletely understood. Patient dermal fibroblasts were reprogrammed to hiPSC, isogenic controls were established by CRISPR/Cas9, and cardiomyocytes were differentiated. Mutant cardiomyocytes revealed significantly prolonged Ca
Identifiants
pubmed: 33998164
doi: 10.15252/emmm.202013074
pmc: PMC8185541
doi:
Substances chimiques
Calcium-Binding Proteins
0
phospholamban
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13074Subventions
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/T2T0119
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RM/13/30157
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/16/3/32406
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/S001808/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/14/1/30588
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/C013202/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L012618/1
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/C013105/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/16/14/32397
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY 4.0 license.
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