Incubation period of COVID-19: A systematic review and meta-analysis.
Coronavirus
Infectious disease incubation period
Período de incubación de enfermedades infecciosas
Public health
Salud pública
Journal
Revista clinica espanola
ISSN: 2254-8874
Titre abrégé: Rev Clin Esp (Barc)
Pays: Spain
ID NLM: 101632437
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
24
06
2020
accepted:
17
08
2020
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
1
6
2021
Statut:
ppublish
Résumé
The incubation period of COVID-19 helps to determine the optimal duration of the quarantine and inform predictive models of incidence curves. Several emerging studies have produced varying results; this systematic review aims to provide a more accurate estimate of the incubation period of COVID-19. For this systematic review, a literature search was conducted using Pubmed, Scopus/EMBASE, and the Cochrane Library databases, covering all observational and experimental studies reporting the incubation period and published from 1 January 2020 to 21 March 2020.We estimated the mean and 95th percentile of the incubation period using meta-analysis, taking into account between-study heterogeneity, and the analysis with moderator variables. We included seven studies (n=792) in the meta-analysis. The heterogeneity (I Based on the published data reporting the incubation period of COVID-19, the mean time between exposure and onset of clinical symptoms depended on the statistical model used, and the 95th percentile depended on the mean age of the patients. It is advisable to record sex and age when collecting data in order to analyze possible differential patterns.
Sections du résumé
BACKGROUND AND OBJECTIVE
The incubation period of COVID-19 helps to determine the optimal duration of the quarantine and inform predictive models of incidence curves. Several emerging studies have produced varying results; this systematic review aims to provide a more accurate estimate of the incubation period of COVID-19.
METHODS
For this systematic review, a literature search was conducted using Pubmed, Scopus/EMBASE, and the Cochrane Library databases, covering all observational and experimental studies reporting the incubation period and published from 1 January 2020 to 21 March 2020.We estimated the mean and 95th percentile of the incubation period using meta-analysis, taking into account between-study heterogeneity, and the analysis with moderator variables.
RESULTS
We included seven studies (n=792) in the meta-analysis. The heterogeneity (I
CONCLUSION
Based on the published data reporting the incubation period of COVID-19, the mean time between exposure and onset of clinical symptoms depended on the statistical model used, and the 95th percentile depended on the mean age of the patients. It is advisable to record sex and age when collecting data in order to analyze possible differential patterns.
Identifiants
pubmed: 33998486
pii: S2254-8874(20)30146-6
doi: 10.1016/j.rceng.2020.08.002
pmc: PMC7698828
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109-117Informations de copyright
Copyright © 2020 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.
Références
Int J Infect Dis. 2020 May;94:68-71
pubmed: 32179140
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Stat Med. 2005 Nov 30;24(22):3431-45
pubmed: 16237660
Am J Hyg. 1950 May;51(3):310-8
pubmed: 15413610
Epidemiol Infect. 2017 Aug;145(11):2241-2253
pubmed: 28669361
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Apr 10;41(4):461-465
pubmed: 32113196
J Med Virol. 2020 May;92(5):476-478
pubmed: 32056235
Ann Intern Med. 2020 May 5;172(9):577-582
pubmed: 32150748
J Infect. 2020 Apr;80(4):401-406
pubmed: 32112886
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Apr 10;41(4):489-493
pubmed: 32133830
Euro Surveill. 2020 Mar;25(10):
pubmed: 32183930
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Sci Rep. 2016 Oct 24;6:35839
pubmed: 27775012
Euro Surveill. 2020 Feb;25(5):
pubmed: 32046819
QJM. 2020 Jul 1;113(7):474-481
pubmed: 32181807
Epidemiol Health. 2020;42:e2020007
pubmed: 32035431
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
BMJ. 2020 Feb 19;368:m606
pubmed: 32075786
BMC Infect Dis. 2018 Sep 27;18(1):483
pubmed: 30261843
Infect Control Hosp Epidemiol. 2020 May;41(5):594-596
pubmed: 32183920
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142
pubmed: 31643080
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
J Clin Med. 2020 Feb 17;9(2):
pubmed: 32079150