Comparative incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients versus kidney or kidney-pancreas waitlisted patients: A single-center study.
COVID-19
epidemiology
kidney transplant
kidney waitlist
Journal
Clinical transplantation
ISSN: 1399-0012
Titre abrégé: Clin Transplant
Pays: Denmark
ID NLM: 8710240
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
07
05
2021
received:
01
04
2021
accepted:
10
05
2021
pubmed:
18
5
2021
medline:
5
10
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
COVID-19 epidemiologic studies comparing immunosuppressed and immunocompetent patients may provide insight into the impact of immunosuppressants on outcomes. In this retrospective cohort study, we assembled kidney or kidney-pancreas transplant recipients who underwent transplant from January 1, 2010, to June 30, 2020, and kidney or kidney-pancreas waitlisted patients who were ever on the waitlist from January 1, 2019, to June 30, 2020. We identified laboratory-confirmed COVID-19 until January 31, 2021, and tracked its outcomes by leveraging informatics infrastructure developed for an outcomes research network. COVID-19 was identified in 62 of 887 kidney or kidney-pancreas transplant recipients and 20 of 434 kidney or kidney-pancreas waitlisted patients (7.0% vs. 4.6%, p = .092). Of these patients with COVID-19, hospitalization occurred in 48 of 62 transplant recipients and 8 of 20 waitlisted patients (77% vs. 40%, p = .002); intensive care unit admission occurred in 18 of 62 transplant recipients and 2 of 20 waitlisted patients (29% vs. 10%, p = .085); and 7 transplant recipients were mechanically ventilated and died, whereas no waitlisted patients were mechanically ventilated or died (11% vs. 0%, p = .116). Our study provides single-center data and an informatics approach that can be used to inform the design of multicenter studies.
Sections du résumé
BACKGROUND
COVID-19 epidemiologic studies comparing immunosuppressed and immunocompetent patients may provide insight into the impact of immunosuppressants on outcomes.
METHODS
In this retrospective cohort study, we assembled kidney or kidney-pancreas transplant recipients who underwent transplant from January 1, 2010, to June 30, 2020, and kidney or kidney-pancreas waitlisted patients who were ever on the waitlist from January 1, 2019, to June 30, 2020. We identified laboratory-confirmed COVID-19 until January 31, 2021, and tracked its outcomes by leveraging informatics infrastructure developed for an outcomes research network.
RESULTS
COVID-19 was identified in 62 of 887 kidney or kidney-pancreas transplant recipients and 20 of 434 kidney or kidney-pancreas waitlisted patients (7.0% vs. 4.6%, p = .092). Of these patients with COVID-19, hospitalization occurred in 48 of 62 transplant recipients and 8 of 20 waitlisted patients (77% vs. 40%, p = .002); intensive care unit admission occurred in 18 of 62 transplant recipients and 2 of 20 waitlisted patients (29% vs. 10%, p = .085); and 7 transplant recipients were mechanically ventilated and died, whereas no waitlisted patients were mechanically ventilated or died (11% vs. 0%, p = .116).
CONCLUSIONS
Our study provides single-center data and an informatics approach that can be used to inform the design of multicenter studies.
Identifiants
pubmed: 33998716
doi: 10.1111/ctr.14362
pmc: PMC8209946
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14362Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Kidney Int. 2020 Jun;97(6):1076-1082
pubmed: 32354637
N Engl J Med. 2020 Sep 3;383(10):994
pubmed: 32649078
Liver Transpl. 2020 Jun;26(6):832-834
pubmed: 32196933
Clin Microbiol Infect. 2014 Sep;20 Suppl 7:102-8
pubmed: 26451405
Am J Transplant. 2020 Jul;20(7):1947-1948
pubmed: 32243698
Am J Transplant. 2020 Jul;20(7):1819-1825
pubmed: 32351040
EGEMS (Wash DC). 2018 Apr 13;6(1):3
pubmed: 29881761
Am J Transplant. 2020 Nov;20(11):2997-3007
pubmed: 32515544
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
N Engl J Med. 2021 Feb 11;384(6):497-511
pubmed: 33264556
Am J Nephrol. 2020;51(5):337-342
pubmed: 32222713
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):607-11
pubmed: 24821736
Transplantation. 2014 Jul 27;98(2):187-94
pubmed: 24621539
Transplantation. 2018 Jun;102(6):898-899
pubmed: 29677079
N Engl J Med. 2020 Jun 18;382(25):2475-2477
pubmed: 32329975
J Am Soc Nephrol. 2017 Apr;28(4):1314-1325
pubmed: 27821629
N Engl J Med. 2020 Jun 11;382(24):2372-2374
pubmed: 32302078
J Am Soc Nephrol. 2020 Jun;31(6):1150-1156
pubmed: 32317402
Am J Transplant. 2021 Apr;21(4):1576-1585
pubmed: 33043597
Am J Transplant. 2020 Nov;20(11):3008-3018
pubmed: 32780493
Am J Transplant. 2007 May;7(5):1209-14
pubmed: 17286615
Am J Kidney Dis. 2020 Jul;76(1):141-143
pubmed: 32240718
Kidney Int. 2020 Jun;97(6):1083-1088
pubmed: 32354634
Clin Transplant. 2021 Aug;35(8):e14362
pubmed: 33998716
Int J Surg. 2014 Dec;12(12):1495-9
pubmed: 25046131
Clin Infect Dis. 2018 Feb 1;66(4):608-611
pubmed: 29028978