Novel Mixed NOP/Opioid Receptor Peptide Agonists.

Animals Binding Sites Cough / chemically induced Disease Models, Animal Guinea Pigs Humans Hydrophobic and Hydrophilic Interactions Male Molecular Dynamics Simulation Peptides / chemistry Receptors, Opioid / agonists Receptors, Opioid, mu / agonists Recombinant Proteins / biosynthesis Structure-Activity Relationship Nociceptin Receptor

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
27 05 2021
Historique:
pubmed: 18 5 2021
medline: 22 6 2021
entrez: 17 5 2021
Statut: ppublish

Résumé

The nociceptin/orphanin FQ (N/OFQ)/N/OFQ receptor (NOP) system controls different biological functions including pain and cough reflex. Mixed NOP/opioid receptor agonists elicit similar effects to strong opioids but with reduced side effects. In this work, 31 peptides with the general sequence [Tyr/Dmt

Identifiants

DOI: 10.1021/acs.jmedchem.0c02062 PMID: 33998786 PMC: PMC8279409
pubmed: 33998786
doi: 10.1021/acs.jmedchem.0c02062
pmc: PMC8279409
doi:

Substances chimiques

Peptides 0
Receptors, Opioid 0
Receptors, Opioid, mu 0
Recombinant Proteins 0
Nociceptin Receptor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6656-6669

Références

Methods Mol Biol. 2013;937:293-306
pubmed: 23007594
Nature. 1995 Oct 12;377(6549):532-5
pubmed: 7566152
Br J Anaesth. 2019 Jun;122(6):e136-e145
pubmed: 31010646
Respir Med. 1991 Jan;85 Suppl A:43-6
pubmed: 1852031
Br J Pharmacol. 2001 Mar;132(6):1175-8
pubmed: 11250866
Pulm Pharmacol Ther. 2002;15(3):213-6
pubmed: 12099766
Br J Anaesth. 2019 Jun;122(6):e146-e156
pubmed: 30916003
PLoS One. 2016 Jun 07;11(6):e0156897
pubmed: 27272042
Nature. 2018 Jun;558(7711):547-552
pubmed: 29899455
Sci Transl Med. 2018 Aug 29;10(456):
pubmed: 30158150
Pharmacology. 2009;84(3):153-61
pubmed: 19696521
Neuropharmacology. 2020 Apr;166:107678
pubmed: 31278929
J Biol Chem. 1996 Sep 27;271(39):23642-5
pubmed: 8798582
Pharmacol Rev. 2003 Dec;55(4):597-606
pubmed: 14657418
Int J Med Chem. 2012;2012:327257
pubmed: 25954526
Org Lett. 2017 Jan 6;19(1):246-249
pubmed: 28026185
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
J Chem Inf Model. 2019 Feb 25;59(2):818-831
pubmed: 30640458
Br J Anaesth. 2018 Nov;121(5):1105-1114
pubmed: 30336855
Eur J Pharmacol. 2017 Jan 5;794:115-126
pubmed: 27871910
J Comput Aided Mol Des. 2018 Feb;32(2):385-400
pubmed: 29340866
Biochemistry. 1986 Oct 7;25(20):6335-42
pubmed: 3024707
Annu Rev Pharmacol Toxicol. 1980;20:81-110
pubmed: 6247963
Nature. 2012 Mar 21;485(7398):321-6
pubmed: 22437502
Nature. 2015 Aug 20;524(7565):315-21
pubmed: 26245379
Nature. 2012 May 16;485(7398):400-4
pubmed: 22596164
J Med Chem. 2011 Apr 14;54(7):2029-38
pubmed: 21366266
Bioorg Med Chem. 2014 Jul 15;22(14):3703-12
pubmed: 24878361
J Med Chem. 2005 Mar 24;48(6):1713-6
pubmed: 15771416
J Neurosci Res. 2020 Apr 7;:
pubmed: 32255240
PLoS One. 2018 Aug 30;13(8):e0203021
pubmed: 30161182
Pharmacol Rev. 2016 Apr;68(2):419-57
pubmed: 26956246
Expert Opin Pharmacother. 2011 Aug;12(11):1745-55
pubmed: 21524236
J Med Chem. 2013 Apr 25;56(8):3207-16
pubmed: 23438330
Nature. 2012 May 16;485(7398):395-9
pubmed: 22596163
J Pharmacol Exp Ther. 2014 Jun;349(3):535-48
pubmed: 24713140
Naunyn Schmiedebergs Arch Pharmacol. 2009 Jun;379(6):599-607
pubmed: 19183962
Handb Exp Pharmacol. 2019;254:323-343
pubmed: 30879202
J Med Chem. 2020 Mar 12;63(5):2673-2687
pubmed: 31834798
Br J Pharmacol. 2014 Aug;171(16):3777-800
pubmed: 24762001
Naunyn Schmiedebergs Arch Pharmacol. 1999 Sep;360(3):270-7
pubmed: 10543428
Am J Respir Crit Care Med. 2006 Feb 1;173(3):271-5
pubmed: 16239621
Science. 1995 Nov 3;270(5237):792-4
pubmed: 7481766
Pharmacology. 2004 Jul;71(3):143-9
pubmed: 15161996
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Br J Pharmacol. 2008 Oct;155(4):547-57
pubmed: 18695648
Mol Psychiatry. 2021 Jan;26(1):218-233
pubmed: 32020048
Br J Pharmacol. 2013 Jan;168(1):151-62
pubmed: 22827708
Nat Rev Drug Discov. 2008 Aug;7(8):694-710
pubmed: 18670432
Proteins. 2006 Nov 15;65(3):712-25
pubmed: 16981200
Handb Exp Pharmacol. 2019;254:165-186
pubmed: 31119465
Bioorg Med Chem. 2015 Apr 1;23(7):1515-20
pubmed: 25716007
Assay Drug Dev Technol. 2011 Aug;9(4):362-72
pubmed: 21323580
J Med Chem. 2015 Nov 12;58(21):8573-83
pubmed: 26465170
Nature. 2014 Feb 13;506(7487):191-6
pubmed: 24413399
Br J Pharmacol. 2018 Jun;175(11):2013-2027
pubmed: 29352503
Biopolymers. 2003;71(2):86-102
pubmed: 12767112
Pharmacol Res Perspect. 2016 Aug 02;4(4):e00247
pubmed: 28116100
FEBS Lett. 1997 Nov 17;417(3):333-6
pubmed: 9409745
Handb Exp Pharmacol. 2019;254:367-398
pubmed: 30927089
Bioconjug Chem. 2019 Sep 18;30(9):2444-2451
pubmed: 31461266

Auteurs

Salvatore Pacifico (S)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.
ORCID: 0000-0002-3377-5107

Valentina Albanese (V)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.

Davide Illuminati (D)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.

Erika Marzola (E)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.

Martina Fabbri (M)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.

Federica Ferrari (F)

Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, Ferrara 44121, Italy.

Victor A D Holanda (VAD)

Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, Ferrara 44121, Italy.

Chiara Sturaro (C)

Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, Ferrara 44121, Italy.

Davide Malfacini (D)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Meneghetti 2, Padova 35131, Italy.

Chiara Ruzza (C)

Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, Ferrara 44121, Italy.
Technopole of Ferrara, LTTA Laboratory for Advanced Therapies, via Fossato di Mortara 70, Ferrara 44121, Italy.

Claudio Trapella (C)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.
Technopole of Ferrara, LTTA Laboratory for Advanced Therapies, via Fossato di Mortara 70, Ferrara 44121, Italy.

Delia Preti (D)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.
ORCID: 0000-0002-1075-3781

Ettore Lo Cascio (E)

Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Roma 00168, Italy.

Alessandro Arcovito (A)

Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Roma 00168, Italy.
Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, Roma 00168, Italy.

Stefano Della Longa (S)

Department of Life, Health and Environmental Sciences, University of L'Aquila, Pza S. Tommasi 1, L'Aquila 67100, Italy.
ORCID: 0000-0002-8157-9530

Martina Marangoni (M)

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale Pieraccini, 6, Florence 50139, Italy.

Davide Fattori (D)

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale Pieraccini, 6, Florence 50139, Italy.

Romina Nassini (R)

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale Pieraccini, 6, Florence 50139, Italy.

Girolamo Calò (G)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Meneghetti 2, Padova 35131, Italy.

Remo Guerrini (R)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.
Technopole of Ferrara, LTTA Laboratory for Advanced Therapies, via Fossato di Mortara 70, Ferrara 44121, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Toux › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Cochons d'Inde › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Novel Mixed NOP/Opioid Receptor Peptide Agonists.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur de la nociceptine › Novel Mixed NOP/Opioid Receptor Peptide Agonists.