Effect of omega-3 fatty acids supplementation on adipokines: a systematic review and meta-analysis of randomized controlled trials.

Adipokines Adiponectin Dietary Supplements Fatty Acids, Omega-3 / pharmacology Humans Leptin Randomized Controlled Trials as Topic
Adipokines adiponectin leptin meta-analysis omega-3 FAs systematic review

Journal

Critical reviews in food science and nutrition
ISSN: 1549-7852
Titre abrégé: Crit Rev Food Sci Nutr
Pays: United States
ID NLM: 8914818

Informations de publication

Date de publication:
2022
Historique:
pubmed: 18 5 2021
medline: 24 9 2022
entrez: 17 5 2021
Statut: ppublish

Résumé

Although a large body of literature reported the beneficial effects of omega-3 fatty acids (omega-3 FAs) consumption on adipokines levels, but recent findings from clinical trials are not univocal. The aim of this systematic review and meta-analysis was to evaluate the effect of omega-3 FAs supplements on adipokines. We searched Medline, Web of Science, Scopus, Embase, and Cochrane Library from inception to August 2020 without any particular language limitations. Outcomes were summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) estimated from Hedge's g and random effects modeling. Fifty-two trials involving 4,568 participants were included. Omega-3 FAs intake was associated with a significant increase in plasma adiponectin levels ( The evidence supports a beneficial effect of omega-3 FAs intake on serum adiponectin levels but does not appear to impact on leptin concentrations. Larger well-designed RCTs are still required to evaluate the effect of omega-3 FAs on leptin in specific diseases.

Sections du résumé

BACKGROUND UNASSIGNED
Although a large body of literature reported the beneficial effects of omega-3 fatty acids (omega-3 FAs) consumption on adipokines levels, but recent findings from clinical trials are not univocal. The aim of this systematic review and meta-analysis was to evaluate the effect of omega-3 FAs supplements on adipokines.
METHODS UNASSIGNED
We searched Medline, Web of Science, Scopus, Embase, and Cochrane Library from inception to August 2020 without any particular language limitations. Outcomes were summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) estimated from Hedge's g and random effects modeling.
RESULTS UNASSIGNED
Fifty-two trials involving 4,568 participants were included. Omega-3 FAs intake was associated with a significant increase in plasma adiponectin levels (
CONCLUSION UNASSIGNED
The evidence supports a beneficial effect of omega-3 FAs intake on serum adiponectin levels but does not appear to impact on leptin concentrations. Larger well-designed RCTs are still required to evaluate the effect of omega-3 FAs on leptin in specific diseases.

Identifiants

DOI: 10.1080/10408398.2021.1915743 PMID: 33998914
pubmed: 33998914
doi: 10.1080/10408398.2021.1915743
doi:

Substances chimiques

Adipokines 0
Adiponectin 0
Fatty Acids, Omega-3 0
Leptin 0

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

7561-7575

Auteurs

Mahdi Sepidarkish (M)

Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, Iran.

Gholamreza Rezamand (G)

Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.

Mostafa Qorbani (M)

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Hafez Heydari (H)

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.

M Dulce Estêvão (MD)

Universidade do Algarve, Escola Superior de Saúde, Campus de Gambelas, Faro, Portugal.

Dalia Omran (D)

Department of Endemic Medicine and Hepatology, Thabet hospital for Endemic diseases, Faculty of Medicine, Cairo University, Cairo, Egypt.

Mojgan Morvaridzadeh (M)

Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Darren M Roffey (DM)

Vancouver General Hospital, Vancouver Coastal Health, Vancouver, Canada.

Farnaz Farsi (F)

Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Sara Ebrahimi (S)

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.

Fatemeh Shokri (F)

Department of Health Education and Promotion, Iran University of Medical Sciences, Tehran, Iran.

Javad Heshmati (J)

Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Effect of omega-3 fatty acids supplementation...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Adiponectine › Effect of omega-3 fatty acids supplementation...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Effect of omega-3 fatty acids supplementation...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Effect of omega-3 fatty acids supplementation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of omega-3 fatty acids supplementation...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Leptine › Effect of omega-3 fatty acids supplementation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Effect of omega-3 fatty acids supplementation...