Lower-body dynamic exercise reduces wave reflection in healthy young adults.
central blood pressure
lower-body dynamic exercise
wave reflection
wave separation analysis
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
11
03
2021
accepted:
14
05
2021
pubmed:
18
5
2021
medline:
1
4
2022
entrez:
17
5
2021
Statut:
ppublish
Résumé
What is the central question of this study? There is a paradoxical reduction in augmentation index during lower-body dynamic (LBD) exercise in the face of an increase in central pressure. To determine causality, the amplitudes of forward and backward pressure waves were assessed separately using wave separation analysis. What is the main finding and its importance? Reflection magnitude decreased during LBD exercise in healthy young adults and was attributable to an increased forward pressure wave amplitude and decreased backward pressure wave amplitude. This vasoactive response might limit the adverse effects of wave reflection during LBD exercise, optimizing ventricular-arterial interactions. Acute lower-body dynamic (LBD) exercise decreases surrogate measures of wave reflection, such as the augmentation index. However, the augmentation index is influenced by the combined effects of wave reflection timing, magnitude and other confounding factors external to wave reflection, which make it difficult to discern the origin of changes in surrogate measures. The relative contributions of forward (Pf) and backward (Pb) pressure wave amplitudes to central pressure can be determined by wave separation analysis. Reflection magnitude (RM = Pb/Pf) and the timing of apparent wave reflection return can also be determined. We tested the hypothesis that acute LBD exercise decreases RM and reflected wave transit time (RWTT). Applanation tonometry was used to record radial artery pressure waveforms in 25 adults (24 ± 4 years of age) at baseline and during light-, moderate- and vigorous-intensity exercise. Wave separation analysis was conducted offline using a personalized physiological flow wave to determine Pf, Pb, RM and RWTT. The RM decreased during all intensities of exercise compared with baseline (all P < 0.001; baseline, 43 ± 5%; light, 33 ± 6%; moderate, 23 ± 7%; vigorous, 17 ± 5%). The reduction in RM was attributable to the combined effect of increased Pf and decreased Pb during exercise. The RWTT decreased during all intensities of exercise compared with baseline (all P < 0.04; baseline, 156 ± 17 ms; light, 144 ± 15 ms; moderate, 129 ± 16 ms; vigorous, 121 ± 17 ms). Lastly, in a stepwise multilinear regression, Pf, but not Pb and RWTT, contributed to increased central pulse pressure during LBD exercise. These data show that wave reflection decreased and that central pulse pressure is most influenced by Pf during LBD exercise.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1720-1730Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM113125
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL121510
Pays : United States
Organisme : NHLBI NIH HHS
ID : R33 HL146390
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153646
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058969
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104106
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL094307
Pays : United States
Organisme : NHLBI NIH HHS
ID : R03 HL146874
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL136730
Pays : United States
Informations de copyright
© 2021 The Authors. Experimental Physiology © 2021 The Physiological Society.
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