Of mice and men - and guinea pigs?
Gametolog
Genome
Guinea pig
NLGN4
Pseudoautosomal region
Journal
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
ISSN: 1618-0402
Titre abrégé: Ann Anat
Pays: Germany
ID NLM: 100963897
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
31
03
2021
revised:
28
04
2021
accepted:
29
04
2021
pubmed:
18
5
2021
medline:
17
11
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
This year marks the twentieth anniversary of the publication of the first draft of the human genome and its broad availability to the scientific community. In parallel, the annotation of the mouse genome led to the identification and analysis of countless genes by means of genetic manipulation. Today, when comparing both genomes, it might surprise that some genes are still seeking their respective homologs in either species. In this review, we aim at raising awareness for the remarkable differences between the researcher's favorite rodents, i.e., mice and rats, when it comes to the generation of rodent research models regarding genes with a particular delicate localization, namely the pseudoautosomal region on both sex chromosomes. Many of these genes are of utmost clinical relevance in humans and still miss a rodent disease model giving their absence in mice and rats or low sequence similarity compared to humans. The abundance of rodents within mammals prompted us to investigate different branches of rodents leading us to the re-discovery of the guinea pig as a mammalian research model for a distinct group of genes.
Identifiants
pubmed: 34000371
pii: S0940-9602(21)00091-1
doi: 10.1016/j.aanat.2021.151765
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
151765Informations de copyright
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