Short hydrogen bonds enhance nonaromatic protein-related fluorescence.
intrinsic fluorescence
short hydrogen bond
ultraviolet fluorescence
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
25 05 2021
25 05 2021
Historique:
entrez:
18
5
2021
pubmed:
19
5
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Fluorescence in biological systems is usually associated with the presence of aromatic groups. Here, by employing a combined experimental and computational approach, we show that specific hydrogen bond networks can significantly affect fluorescence. In particular, we reveal that the single amino acid L-glutamine, by undergoing a chemical transformation leading to the formation of a short hydrogen bond, displays optical properties that are significantly enhanced compared with L-glutamine itself. Ab initio molecular dynamics simulations highlight that these short hydrogen bonds prevent the appearance of a conical intersection between the excited and the ground states and thereby significantly decrease nonradiative transition probabilities. Our findings open the door to the design of new photoactive materials with biophotonic applications.
Identifiants
pubmed: 34001606
pii: 2020389118
doi: 10.1073/pnas.2020389118
pmc: PMC8166056
pii:
doi:
Substances chimiques
Peptides
0
Glutamine
0RH81L854J
polyglutamine
26700-71-0
Ammonia
7664-41-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K02292X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 065807/Z/01/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Chem Phys. 2014 Apr 28;140(16):164105
pubmed: 24784251
Sci Rep. 2016 Nov 14;6:37161
pubmed: 27841335
Science. 2001 Mar 16;291(5511):2121-4
pubmed: 11251111
J Phys Chem A. 2015 Nov 5;119(44):10816-27
pubmed: 26444383
Analyst. 2013 Apr 7;138(7):2156-62
pubmed: 23420088
Biochemistry. 2008 Jan 22;47(3):978-85
pubmed: 18154360
J Chem Phys. 2018 Mar 14;148(10):102331
pubmed: 29544302
Phys Rev Lett. 2007 Jan 12;98(2):023001
pubmed: 17358601
Ann Hum Genet. 2007 May;71(Pt 3):295-301
pubmed: 17181545
J Phys Chem B. 2014 Dec 4;118(48):13903-12
pubmed: 25415885
Phys Rev B Condens Matter. 1996 Jul 15;54(3):1703-1710
pubmed: 9986014
Chem Sci. 2019 Jul 1;10(33):7734-7745
pubmed: 31588321
Phys Chem Chem Phys. 2008 Nov 28;10(44):6615-20
pubmed: 18989472
Arch Biochem Biophys. 2004 Aug 15;428(2):144-53
pubmed: 15246870
EMBO J. 2002 Nov 1;21(21):5682-90
pubmed: 12411486
Nano Lett. 2009 Sep;9(9):3111-5
pubmed: 19736968
J Am Chem Soc. 2012 May 23;134(20):8557-69
pubmed: 22500856
Langmuir. 2016 Mar 29;32(12):2847-62
pubmed: 26496411
Nat Commun. 2016 Jul 15;7:12116
pubmed: 27418042
J Chem Phys. 2010 Apr 21;132(15):154104
pubmed: 20423165
J Phys Condens Matter. 2017 Oct 24;29(46):465901
pubmed: 29064822
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18019-24
pubmed: 17984067
J Am Chem Soc. 2020 Oct 21;142(42):18042-18049
pubmed: 32966740
J Chem Phys. 2016 Nov 28;145(20):205102
pubmed: 27908111
PLoS One. 2017 May 25;12(5):e0176983
pubmed: 28542206
Phys Chem Chem Phys. 2013 Nov 14;15(42):18336-48
pubmed: 24068257
Chem Soc Rev. 2014;43(20):7236
pubmed: 25723149
J Chem Phys. 2008 Apr 21;128(15):154105
pubmed: 18433188
Science. 2017 Nov 17;358(6365):
pubmed: 29146781
Chemphyschem. 2006 Sep 11;7(9):1848-70
pubmed: 16929553
Phys Chem Chem Phys. 2017 Feb 1;19(5):4030-4040
pubmed: 28111679
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):440-4
pubmed: 19122140
Chem Sci. 2017 Aug 1;8(8):5416-5433
pubmed: 28970921
Phys Rev B Condens Matter. 1991 Jan 15;43(3):1993-2006
pubmed: 9997467
Langmuir. 2006 Jan 31;22(3):1313-20
pubmed: 16430299
Phys Rev A Gen Phys. 1988 Sep 15;38(6):3098-3100
pubmed: 9900728
J Phys Chem A. 2020 Nov 19;124(46):9503-9512
pubmed: 33166141
Appl Spectrosc. 2015 Jan;69(1):1-25
pubmed: 25506684
Chembiochem. 2013 May 10;14(7):846-50
pubmed: 23592254
J Phys Chem A. 2016 Feb 18;120(6):939-47
pubmed: 26814572
Arch Biochem Biophys. 2018 Aug 1;651:13-20
pubmed: 29803394
J Biol Chem. 1998 Oct 2;273(40):25529-32
pubmed: 9748211
J Biol Chem. 1992 Aug 25;267(24):17082-6
pubmed: 1512246
J Chem Theory Comput. 2014 Mar 11;10(3):959-67
pubmed: 26580175
J Chem Inf Model. 2017 Jul 24;57(7):1548-1562
pubmed: 28603985
J Chem Phys. 2007 Jan 7;126(1):014101
pubmed: 17212484
Front Chem. 2018 Mar 21;6:70
pubmed: 29619365
Nat Commun. 2018 Jul 17;9(1):2766
pubmed: 30018359
J Phys Chem A. 2019 Mar 7;123(9):1758-1765
pubmed: 30753080
Nat Commun. 2011 Nov 29;2:563
pubmed: 22127059
J Am Chem Soc. 2016 Mar 9;138(9):3046-57
pubmed: 26824778
Faraday Discuss. 2018 Apr 17;207(0):115-135
pubmed: 29359223
Phys Chem Chem Phys. 2019 Nov 21;21(43):23931-23942
pubmed: 31661536