Socioeconomic Disadvantage and the Pace of Biological Aging in Children.

Adolescent Aging / physiology Child DNA / analysis DNA Methylation Female Humans Male Saliva / chemistry Socioeconomic Factors Time Factors Vulnerable Populations

Journal

Pediatrics
ISSN: 1098-4275
Titre abrégé: Pediatrics
Pays: United States
ID NLM: 0376422

Informations de publication

Date de publication:
06 2021
Historique:
accepted: 27 01 2021
pubmed: 19 5 2021
medline: 14 1 2022
entrez: 18 5 2021
Statut: ppublish

Résumé

Children who grow up in socioeconomic disadvantage face increased burden of disease and disability throughout their lives. One hypothesized mechanism for this increased burden is that early-life disadvantage accelerates biological processes of aging, increasing vulnerability to subsequent disease. To evaluate this hypothesis and the potential impact of preventive interventions, measures are needed that can quantify early acceleration of biological aging in childhood. Saliva DNA methylation and socioeconomic circumstances were measured in Children living in more disadvantaged families and neighborhoods exhibited a faster DunedinPoAm-measured pace of aging ( Children growing up under conditions of socioeconomic disadvantage exhibit a faster pace of biological aging. DNA methylation pace of aging might be useful as a surrogate end point in evaluation of programs and policies to address the childhood social determinants of lifelong health disparities.

Sections du résumé

BACKGROUND AND OBJECTIVES
Children who grow up in socioeconomic disadvantage face increased burden of disease and disability throughout their lives. One hypothesized mechanism for this increased burden is that early-life disadvantage accelerates biological processes of aging, increasing vulnerability to subsequent disease. To evaluate this hypothesis and the potential impact of preventive interventions, measures are needed that can quantify early acceleration of biological aging in childhood.
METHODS
Saliva DNA methylation and socioeconomic circumstances were measured in
RESULTS
Children living in more disadvantaged families and neighborhoods exhibited a faster DunedinPoAm-measured pace of aging (
CONCLUSIONS
Children growing up under conditions of socioeconomic disadvantage exhibit a faster pace of biological aging. DNA methylation pace of aging might be useful as a surrogate end point in evaluation of programs and policies to address the childhood social determinants of lifelong health disparities.

Identifiants

DOI: 10.1542/peds.2020-024406 PMID: 34001641 PMC: PMC8785753
pubmed: 34001641
pii: peds.2020-024406
doi: 10.1542/peds.2020-024406
pmc: PMC8785753
pii:
doi:

Substances chimiques

DNA 9007-49-2

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : R01 AG028593
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061378
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066887
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD092548
Pays : United States
Organisme : NICHD NIH HHS
ID : R24 HD042849
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD083613
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG042190
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 by the American Academy of Pediatrics.

Déclaration de conflit d'intérêts

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

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Auteurs

Laurel Raffington (L)

Department of Psychology and laurel.raffington@austin.utexas.edu.
Population Research Center, The University of Texas at Austin, Austin, Texas.

Daniel W Belsky (DW)

Department of Epidemiology and.
The Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, New York; and.

Meeraj Kothari (M)

The Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, New York; and.

Margherita Malanchini (M)

Department of Psychology and.
Population Research Center, The University of Texas at Austin, Austin, Texas.
Department of Biological and Experimental Psychology, Queen Mary University of London, London, United Kingdom.

Elliot M Tucker-Drob (EM)

Department of Psychology and.
Population Research Center, The University of Texas at Austin, Austin, Texas.
Contributed equally as co-lead authors.

K Paige Harden (KP)

Department of Psychology and.
Population Research Center, The University of Texas at Austin, Austin, Texas.
Contributed equally as co-lead authors.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Salive › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Socioeconomic Disadvantage and the Pace of...
questionsmedicales.fr › Personnes › Disparités en matière de santé, minorités et populations vulnérables › Populations vulnérables › Socioeconomic Disadvantage and the Pace of...