Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial.
Journal
Signal transduction and targeted therapy
ISSN: 2059-3635
Titre abrégé: Signal Transduct Target Ther
Pays: England
ID NLM: 101676423
Informations de publication
Date de publication:
17 05 2021
17 05 2021
Historique:
received:
08
02
2021
accepted:
18
03
2021
revised:
08
03
2021
entrez:
18
5
2021
pubmed:
19
5
2021
medline:
1
6
2021
Statut:
epublish
Résumé
Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication. Meplazumab is a humanized anti-CD147 IgG
Identifiants
pubmed: 34001849
doi: 10.1038/s41392-021-00603-6
pii: 10.1038/s41392-021-00603-6
pmc: PMC8127508
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
meplazumab
0EL07E29VQ
Types de publication
Clinical Trial, Phase I
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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