Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries.
Adult
Antibodies, Bacterial
/ blood
Bordetella pertussis
/ drug effects
Diphtheria
/ epidemiology
Diphtheria-Tetanus-Pertussis Vaccine
/ administration & dosage
Europe
/ epidemiology
Humans
Immunoglobulin G
/ blood
Middle Aged
Seroepidemiologic Studies
Tetanus
/ epidemiology
Whooping Cough
/ epidemiology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 05 2021
17 05 2021
Historique:
received:
16
06
2020
accepted:
13
04
2021
entrez:
18
5
2021
pubmed:
19
5
2021
medline:
8
6
2021
Statut:
epublish
Résumé
Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40-49 and 50-59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion of sera with pertussis toxin antibody levels ≥100 IU/mL, indicative of recent exposure to pertussis was comparable for 13/18 countries, ranging between 2.7-5.8%. For diphtheria the proportion of sera lacking the protective level (<0.1 IU/mL) varied between 22.8-82.0%. For tetanus the protection was sufficient. Here, we report that the seroprevalence of pertussis in these age groups indicates circulation of B. pertussis across EU/EEA while the lack of vaccine-induced seroprotection against diphtheria is of concern and deserves further attention.
Identifiants
pubmed: 34001895
doi: 10.1038/s41467-021-23114-y
pii: 10.1038/s41467-021-23114-y
pmc: PMC8128873
doi:
Substances chimiques
Antibodies, Bacterial
0
Diphtheria-Tetanus-Pertussis Vaccine
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2871Investigateurs
Jeffrey van Vliet
(J)
Marjan Bogaard
(M)
Elske van Loghem
(E)
Fiona van der Klis
(F)
Joanna Jasinska
(J)
Denis Piérard
(D)
Charlotte Sværke Jørgensen
(CS)
Sylvain Brisse
(S)
Vasiliki Rapti
(V)
Zsuzsanna Molnar
(Z)
Deirdre Burke
(D)
Vilnele Lipnickiene
(V)
Jelena Galajeva
(J)
Audun Aase
(A)
Sofia Moura
(S)
Mihaela Leustean
(M)
Mia Brytting
(M)
Marta Vitek
(M)
Maria Avdicova
(M)
Gayatri Amirthalingam
(G)
Jussi Mertsola
(J)
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