Seizure frequency discrepancy between subjective and objective ictal electroencephalography data in dogs.

Animals Dog Diseases / diagnosis Dogs Electroencephalography / veterinary Epilepsy / diagnosis Prospective Studies Seizures / diagnosis Status Epilepticus / veterinary
electroencephalography ictal PDs paroxysmal discharges seizure underreporting phenomenon

Journal

Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660

Informations de publication

Date de publication:
Jul 2021
Historique:
revised: 30 04 2021
received: 19 09 2020
accepted: 30 04 2021
pubmed: 19 5 2021
medline: 24 7 2021
entrez: 18 5 2021
Statut: ppublish

Résumé

Many studies of epilepsy in veterinary medicine use subjective data (eg, caregiver-derived histories) to determine seizure frequency. Conversely, in people, objective data from electroencephalography (EEG) are mainly used to diagnose epilepsy, measure seizure frequency and evaluate efficacy of antiseizure drugs. These EEG data minimize the possibility of the underreporting of seizures, a known phenomenon in human epileptology. To evaluate the correlation between reported seizure frequency and EEG frequency of ictal paroxysmal discharges (PDs) and to determine whether seizure underreporting phenomenon exists in veterinary epileptology. Thirty-three ambulatory video-EEG recordings in dogs showing ≥1 ictal PD, excluding dogs with status epilepticus. Retrospective observational study. Ictal PDs were counted manually over the entire recording to obtain the frequency of EEG seizures. Caregiver-reported seizure frequency from the medical record was categorized into weekly, daily, hourly, and per minute seizure groupings. The Spearman rank test was used for correlation analysis. The coefficient value (r A weak correlation was found between the frequency of reported seizures from caregivers (subjective data) and ictal PDs on EEG (objective data). Subjective data may not be reliable enough to determine true seizure frequency given the discrepancy with EEG-confirmed seizure frequency. Confirmation of the seizure underreporting phenomenon in dogs by prospective study should be carried out.

Sections du résumé

BACKGROUND BACKGROUND
Many studies of epilepsy in veterinary medicine use subjective data (eg, caregiver-derived histories) to determine seizure frequency. Conversely, in people, objective data from electroencephalography (EEG) are mainly used to diagnose epilepsy, measure seizure frequency and evaluate efficacy of antiseizure drugs. These EEG data minimize the possibility of the underreporting of seizures, a known phenomenon in human epileptology.
OBJECTIVE OBJECTIVE
To evaluate the correlation between reported seizure frequency and EEG frequency of ictal paroxysmal discharges (PDs) and to determine whether seizure underreporting phenomenon exists in veterinary epileptology.
ANIMALS METHODS
Thirty-three ambulatory video-EEG recordings in dogs showing ≥1 ictal PD, excluding dogs with status epilepticus.
METHODS METHODS
Retrospective observational study. Ictal PDs were counted manually over the entire recording to obtain the frequency of EEG seizures. Caregiver-reported seizure frequency from the medical record was categorized into weekly, daily, hourly, and per minute seizure groupings. The Spearman rank test was used for correlation analysis.
RESULTS RESULTS
The coefficient value (r
CONCLUSIONS AND CLINICAL IMPORTANCE CONCLUSIONS
A weak correlation was found between the frequency of reported seizures from caregivers (subjective data) and ictal PDs on EEG (objective data). Subjective data may not be reliable enough to determine true seizure frequency given the discrepancy with EEG-confirmed seizure frequency. Confirmation of the seizure underreporting phenomenon in dogs by prospective study should be carried out.

Identifiants

DOI: 10.1111/jvim.16158 PMID: 34002887 PMC: PMC8295668
pubmed: 34002887
doi: 10.1111/jvim.16158
pmc: PMC8295668
doi:

Types de publication

Journal Article Observational Study, Veterinary

Langues

eng

Sous-ensembles de citation

IM

Pagination

1819-1825

Subventions

Organisme : Canada Foundation for Innovation
ID : #30953
Organisme : Jane ja Aatos Erkon Säätiö
Organisme : Ontario Veterinary College Pet Trust Fund
ID : #054488

Informations de copyright

© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.

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Auteurs

Masayasu Ukai (M)

Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
ORCID: 0000-0002-4493-9832

Thomas Parmentier (T)

Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
ORCID: 0000-0002-8992-1476

Miguel A Cortez (MA)

Division of Neurology, Department of Paediatrics, Faculty of Medicine, University of Toronto, Peter Gilgan Center Research Learning, SickKids Research Institute, Toronto, Ontario, Canada.

Andrea Fischer (A)

Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, München, Germany.
ORCID: 0000-0001-7094-1947

Luis Gaitero (L)

Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Hannes Lohi (H)

Departments of Medical and Clinical Genetics and Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Folkhälsan Research Center, Helsinki, Finland.

Stephanie Nykamp (S)

Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Tarja S Jokinen (TS)

Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.

Danielle Powers (D)

Neurology and Neurosurgery Service, Animal Medical and Surgical Center, Scottsdale, Arizona, USA.

Veronique Sammut (V)

Neurology Department, VCA West Los Angeles Animal Hospital, Los Angeles, California, USA.

Sean Sanders (S)

Seattle Veterinary Neurosurgery, Seattle, Washington, USA.

Tricia Tai (T)

Neurology Department, VCA West Los Angeles Animal Hospital, Los Angeles, California, USA.

Franziska Wielaender (F)

Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, München, Germany.
ORCID: 0000-0002-3113-5659

Fiona James (F)

Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
ORCID: 0000-0003-4331-4993

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Seizure frequency discrepancy between...
questionsmedicales.fr › Maladies de l'animal › Maladies des chiens › Seizure frequency discrepancy between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Seizure frequency discrepancy between...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électroencéphalographie › Seizure frequency discrepancy between...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Seizure frequency discrepancy between...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Seizure frequency discrepancy between...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Seizure frequency discrepancy between...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › État de mal épileptique › Seizure frequency discrepancy between...