Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lung.
Brainstem
COVID-19
Medulla oblongata
Neurological COVID-19
Neuropathology
SARS-CoV-2
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
10
03
2021
accepted:
05
05
2021
revised:
04
05
2021
pubmed:
19
5
2021
medline:
5
11
2021
entrez:
18
5
2021
Statut:
ppublish
Résumé
SARS-CoV-2 might spread through the nervous system, reaching respiratory centers in the brainstem. Because we recently reported neurophysiological brainstem reflex abnormalities in COVID-19 patients, we here neuropathologically assessed structural brainstem damage in two COVID-19 patients. We assessed neuropathological features in two patients who died of COVID-19 and in two COVID-19 negative patients as controls. Neuronal damage and corpora amylacea (CA) numbers /mm Autopsies showed normal gross brainstem anatomy. Histopathological examination demonstrated increased neuronal and CA damage in Covid-19 patients' medulla oblongata. Immunohistochemistry disclosed SARS-CoV-2 NP in brainstem neurons and glial cells, and in cranial nerves. Glial elements also exhibited a widespread increase in Iba-1 expression. Sars-Co-V2 was immunohistochemically detected in the vagus nerve fibers. Neuropathologic evidence showing SARS-CoV-2 in the brainstem and medullary damage in the area of respiratory centers strongly suggests that the pathophysiology of COVID-19-related respiratory failure includes a neurogenic component. Sars-Co-V2 detection in the vagus nerve, argues for viral trafficking between brainstem and lung.
Identifiants
pubmed: 34003372
doi: 10.1007/s00415-021-10604-8
pii: 10.1007/s00415-021-10604-8
pmc: PMC8129960
doi:
Types de publication
Case Reports
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
4486-4491Subventions
Organisme : Fondazione Romeo ed Enrica Invernizzi
ID : Bando COVID-19
Informations de copyright
© 2021. The Author(s).
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