Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRAS

Acetylcysteine / metabolism Acute Kidney Injury / chemically induced Animals Dose-Response Relationship, Drug Male Piperazines / metabolism Proto-Oncogene Proteins p21(ras) / antagonists & inhibitors Pyridines / metabolism Pyrimidines / metabolism Rats Rats, Sprague-Dawley Signal Transduction / drug effects
KRAS Kidney toxicity Mercapturic acid pathway Metabolite Sotorasib Sprague Dawley rat

Journal

Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575

Informations de publication

Date de publication:
15 07 2021
Historique:
received: 04 03 2021
revised: 12 05 2021
accepted: 13 05 2021
pubmed: 19 5 2021
medline: 23 6 2021
entrez: 18 5 2021
Statut: ppublish

Résumé

Sotorasib is a first-in class KRAS

Identifiants

DOI: 10.1016/j.taap.2021.115578 PMID: 34004237
pubmed: 34004237
pii: S0041-008X(21)00185-X
doi: 10.1016/j.taap.2021.115578
pii:
doi:

Substances chimiques

Kras protein, rat 0
Piperazines 0
Pyridines 0
Pyrimidines 0
sotorasib 2B2VM6UC8G
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2
Acetylcysteine WYQ7N0BPYC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115578

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Jonathan A Werner (JA)

Amgen Research, Translational Safety and Bioanalytical Sciences, Thousand Oaks, CA, USA. Electronic address: jowerner@amgen.com.

Rhian Davies (R)

Amgen Research, Translational Safety and Bioanalytical Sciences, Thousand Oaks, CA, USA.

Jan Wahlstrom (J)

Amgen Research, Pharmacokinetics and Drug Metabolism, South San Francisco, CA, USA.

Upendra P Dahal (UP)

Amgen Research, Pharmacokinetics and Drug Metabolism, South San Francisco, CA, USA.

Min Jiang (M)

Amgen Research, Pharmacokinetics and Drug Metabolism, South San Francisco, CA, USA.

Jonathan Stauber (J)

Imabiotech Corp, Billerica, MA, USA.

Benjamin David (B)

Imabiotech Corp, Billerica, MA, USA.

William Siska (W)

Amgen Research, Translational Safety and Bioanalytical Sciences, Thousand Oaks, CA, USA.

Barbara Thomas (B)

Amgen Research Operations, Thousand Oaks, CA, USA.

Katsu Ishida (K)

Amgen Research, Translational Safety and Bioanalytical Sciences, Thousand Oaks, CA, USA.

W Griffith Humphreys (WG)

Aranmore Pharma Consulting, Lawrenceville, NJ, USA.

J Russell Lipford (JR)

Amgen Research, Oncology, Thousand Oaks, CA, USA.

Thomas M Monticello (TM)

Amgen Research, Translational Safety and Bioanalytical Sciences, Thousand Oaks, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Acétylcystéine › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Eucaryotes › Animaux › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Mercapturate pathway metabolites of sotorasib,...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mercapturate pathway metabolites of sotorasib,...