Cell Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism.
Parkinson's disease
basal ganglia
dopamine
electrophysiology
intrinsic plasticity
motor cortex
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
23 06 2021
23 06 2021
Historique:
received:
20
10
2020
revised:
03
05
2021
accepted:
05
05
2021
pubmed:
20
5
2021
medline:
20
11
2021
entrez:
19
5
2021
Statut:
ppublish
Résumé
The hypokinetic motor symptoms of Parkinson's disease (PD) are closely linked with a decreased motor cortical output as a consequence of elevated basal ganglia inhibition. However, whether and how the loss of dopamine (DA) alters the cellular properties of motor cortical neurons in PD remains undefined. We induced parkinsonism in adult C57BL/6 mice of both sexes by injecting neurotoxin, 6-hydroxydopamine (6-OHDA), into the medial forebrain bundle. By using
Identifiants
pubmed: 34006589
pii: JNEUROSCI.2694-20.2021
doi: 10.1523/JNEUROSCI.2694-20.2021
pmc: PMC8221604
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5553-5565Subventions
Organisme : NINDS NIH HHS
ID : R01 NS121371
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
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